Suprasellar central nervous system ganglioneuroblastoma : a case in a 9-year-old child and review of the literature
PURPOSE: Intracranial ganglioneuroblastomas are incredibly rare neuroectodermal tumors with only 8 described cases total, 5 of those having imaging findings METHODS: Here we present a 9-year-old female patient with 4 months progressive headaches, personality changes, and vomiting. We also present a review of the current literature of intracranial ganglioneuroblastomas.
RESULTS: Imaging demonstrated a partially calcified suprasellar mass measuring 4.6 × 6.3 × 5 cm composed of both solid and cystic components, diagnosed to be a ganglioneuroblastoma, with mass effect on the lateral and 3rd ventricles, with a midline shift of right to left of 6-7 mm. She was treated with subtotal surgical resection, an intensive chemotherapeutic regimen, and radiation and has no residual disease on imaging 1 year and 4 months status post-surgery.
CONCLUSION: To our knowledge, this is the first case of a ganglioneuroblastoma to mimic a craniopharyngioma based upon imaging findings and suprasellar location. As these cases are extremely rare, an optimal therapeutic regimen has not been defined. However, a combination of surgical resection, chemotherapy, and radiation therapy can be effective, as shown here with successful treatment and no evidence of residual disease.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
|---|---|
| Enthalten in: |
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 36(2020), 11 vom: 11. Nov., Seite 2845-2849 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mrowczynski, Oliver D [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Case Reports |
|---|
| Anmerkungen: |
Date Completed 21.06.2021 Date Revised 21.06.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s00381-020-04597-4 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM308316053 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM308316053 | ||
| 003 | DE-627 | ||
| 005 | 20231225131457.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00381-020-04597-4 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1027.xml |
| 035 | |a (DE-627)NLM308316053 | ||
| 035 | |a (NLM)32246193 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mrowczynski, Oliver D |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Suprasellar central nervous system ganglioneuroblastoma |b a case in a 9-year-old child and review of the literature |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 21.06.2021 | ||
| 500 | |a Date Revised 21.06.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: Intracranial ganglioneuroblastomas are incredibly rare neuroectodermal tumors with only 8 described cases total, 5 of those having imaging findings METHODS: Here we present a 9-year-old female patient with 4 months progressive headaches, personality changes, and vomiting. We also present a review of the current literature of intracranial ganglioneuroblastomas | ||
| 520 | |a RESULTS: Imaging demonstrated a partially calcified suprasellar mass measuring 4.6 × 6.3 × 5 cm composed of both solid and cystic components, diagnosed to be a ganglioneuroblastoma, with mass effect on the lateral and 3rd ventricles, with a midline shift of right to left of 6-7 mm. She was treated with subtotal surgical resection, an intensive chemotherapeutic regimen, and radiation and has no residual disease on imaging 1 year and 4 months status post-surgery | ||
| 520 | |a CONCLUSION: To our knowledge, this is the first case of a ganglioneuroblastoma to mimic a craniopharyngioma based upon imaging findings and suprasellar location. As these cases are extremely rare, an optimal therapeutic regimen has not been defined. However, a combination of surgical resection, chemotherapy, and radiation therapy can be effective, as shown here with successful treatment and no evidence of residual disease | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Central nervous system ganglioneuroblastoma | |
| 650 | 4 | |a Ganglioneuroma | |
| 650 | 4 | |a Neuroblastoma | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Suprasellar | |
| 700 | 1 | |a Lane, Jessica R |e verfasserin |4 aut | |
| 700 | 1 | |a Specht, Charles S |e verfasserin |4 aut | |
| 700 | 1 | |a Greiner, Robert J |e verfasserin |4 aut | |
| 700 | 1 | |a Iantosca, Mark R |e verfasserin |4 aut | |
| 700 | 1 | |a Rizk, Elias B |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery |d 1993 |g 36(2020), 11 vom: 11. Nov., Seite 2845-2849 |w (DE-627)NLM012695971 |x 1433-0350 |7 nnns |
| 773 | 1 | 8 | |g volume:36 |g year:2020 |g number:11 |g day:11 |g month:11 |g pages:2845-2849 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00381-020-04597-4 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 36 |j 2020 |e 11 |b 11 |c 11 |h 2845-2849 | ||