Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection : a Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19
© 2020 The Korean Academy of Medical Sciences..
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pneumonia emerged in Wuhan, China in December 2019. In this retrospective multicenter study, we investigated the clinical course and outcomes of novel coronavirus disease 2019 (COVID-19) from early cases in Republic of Korea.
METHODS: All of the cases confirmed by real time polymerase chain reaction were enrolled from the 1st to the 28th patient nationwide. Clinical data were collected and analyzed for changes in clinical severity including laboratory, radiological, and virologic dynamics during the progression of illness.
RESULTS: The median age was 40 years (range, 20-73 years) and 15 (53.6%) patients were male. The most common symptoms were cough (28.6%) and sore throat (28.6%), followed by fever (25.0%). Diarrhea was not common (10.7%). Two patients had no symptoms. Initial chest X-ray (CXR) showed infiltration in 46.4% of the patients, but computed tomography scan confirmed pneumonia in 88.9% (16/18) of the patients. Six patients (21.4%) required supplemental oxygen therapy, but no one needed mechanical ventilation. Lymphopenia was more common in severe cases. Higher level of C-reactive protein and worsening of chest radiographic score was observed during the 5-7 day period after symptom onset. Viral shedding was high from day 1 of illness, especially from the upper respiratory tract (URT).
CONCLUSION: The prodromal symptoms of COVID-19 were mild and most patients did not have limitations of daily activity. Viral shedding from URT was high from the prodromal phase. Radiological pneumonia was common from the early days of illness, but it was frequently not evident in simple CXR. These findings could be plausible explanations for the easy and rapid spread of SARS-CoV-2 in the community.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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| Enthalten in: |
Journal of Korean medical science - 35(2020), 13 vom: 06. Apr., Seite e142 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kim, Eu Suk [VerfasserIn] |
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| Links: |
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| Themen: |
9007-41-4 |
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| Anmerkungen: |
Date Completed 06.04.2020 Date Revised 28.03.2024 published: Electronic CommentIn: Nicotine Tob Res. 2020 Nov 27;:. - PMID 33244597 Citation Status MEDLINE |
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| doi: |
10.3346/jkms.2020.35.e142 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM308278070 |
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| 100 | 1 | |a Kim, Eu Suk |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection |b a Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19 |
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| 500 | |a Date Revised 28.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a CommentIn: Nicotine Tob Res. 2020 Nov 27;:. - PMID 33244597 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 The Korean Academy of Medical Sciences. | ||
| 520 | |a BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pneumonia emerged in Wuhan, China in December 2019. In this retrospective multicenter study, we investigated the clinical course and outcomes of novel coronavirus disease 2019 (COVID-19) from early cases in Republic of Korea | ||
| 520 | |a METHODS: All of the cases confirmed by real time polymerase chain reaction were enrolled from the 1st to the 28th patient nationwide. Clinical data were collected and analyzed for changes in clinical severity including laboratory, radiological, and virologic dynamics during the progression of illness | ||
| 520 | |a RESULTS: The median age was 40 years (range, 20-73 years) and 15 (53.6%) patients were male. The most common symptoms were cough (28.6%) and sore throat (28.6%), followed by fever (25.0%). Diarrhea was not common (10.7%). Two patients had no symptoms. Initial chest X-ray (CXR) showed infiltration in 46.4% of the patients, but computed tomography scan confirmed pneumonia in 88.9% (16/18) of the patients. Six patients (21.4%) required supplemental oxygen therapy, but no one needed mechanical ventilation. Lymphopenia was more common in severe cases. Higher level of C-reactive protein and worsening of chest radiographic score was observed during the 5-7 day period after symptom onset. Viral shedding was high from day 1 of illness, especially from the upper respiratory tract (URT) | ||
| 520 | |a CONCLUSION: The prodromal symptoms of COVID-19 were mild and most patients did not have limitations of daily activity. Viral shedding from URT was high from the prodromal phase. Radiological pneumonia was common from the early days of illness, but it was frequently not evident in simple CXR. These findings could be plausible explanations for the easy and rapid spread of SARS-CoV-2 in the community | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Chin, Bum Sik |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Chang Kyung |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Nam Joong |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Yu Min |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Jae Phil |e verfasserin |4 aut | |
| 700 | 1 | |a Oh, Dong Hyun |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Jeong Han |e verfasserin |4 aut | |
| 700 | 1 | |a Koh, Boram |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Seong Eun |e verfasserin |4 aut | |
| 700 | 1 | |a Yun, Na Ra |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Jae Hoon |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Jin Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Yeonjae |e verfasserin |4 aut | |
| 700 | 1 | |a Bang, Ji Hwan |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Kyoung Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Hong Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Chung, Ki Hyun |e verfasserin |4 aut | |
| 700 | 1 | |a Oh, Myoung Don |e verfasserin |4 aut | |
| 700 | 0 | |a Korea National Committee for Clinical Management of COVID-19 |e verfasserin |4 aut | |
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