Are cytochrome P4502D6 and apolipoprotein E genotypes associated with long-term cognitive and functional changes in patients treated with donepezil?
© 2020 Japanese Psychogeriatric Society..
AIM: We investigated the associations of the single-nucleotide polymorphism rs1080985 of cytochrome P4502D6 (CYP2D6) and the apolipoprotein E (APOE) genotypes with cognitive and functional changes in patients treated with donepezil.
METHODS: Sixty-five outpatients with Alzheimer's disease or mixed dementia being treated with donepezil were assessed at baseline and over 27 months. Changes in cognitive status, assessed with the Mini-Mental State Examination, and in functional status, assessed by the Activities of Daily Living Scale and the Instrumental Activities of Daily Living Scale, were evaluated as a function of CYP2D6 and APOE genotypes by using linear mixed models. Multiplicative interactions between the CYP2D6 and APOE genotypes and time were investigated.
RESULTS: Individuals with the mutated CYP2D6 exhibited a slower decline in total Mini-Mental State Examination scores, orientation, registration, and functional status than those with the wild type. A significant interaction between CYP2D6, APOE, and time was found for changes in the Activities of Daily Living Scale; among the ε4 carriers, those with the mutated CYP2D6 exhibited a slower decline on the Activities of Daily Living Scale than those with the wild type.
CONCLUSION: The CYP2D6 and APOE genotypes may modulate the effectiveness of donepezil on cognitive and functional status.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society - 20(2020), 5 vom: 03. Sept., Seite 578-584 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pamio, Maria V [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 04.02.2021 Date Revised 04.02.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/psyg.12547 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM30822793X |
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| 100 | 1 | |a Pamio, Maria V |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Are cytochrome P4502D6 and apolipoprotein E genotypes associated with long-term cognitive and functional changes in patients treated with donepezil? |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Revised 04.02.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 Japanese Psychogeriatric Society. | ||
| 520 | |a AIM: We investigated the associations of the single-nucleotide polymorphism rs1080985 of cytochrome P4502D6 (CYP2D6) and the apolipoprotein E (APOE) genotypes with cognitive and functional changes in patients treated with donepezil | ||
| 520 | |a METHODS: Sixty-five outpatients with Alzheimer's disease or mixed dementia being treated with donepezil were assessed at baseline and over 27 months. Changes in cognitive status, assessed with the Mini-Mental State Examination, and in functional status, assessed by the Activities of Daily Living Scale and the Instrumental Activities of Daily Living Scale, were evaluated as a function of CYP2D6 and APOE genotypes by using linear mixed models. Multiplicative interactions between the CYP2D6 and APOE genotypes and time were investigated | ||
| 520 | |a RESULTS: Individuals with the mutated CYP2D6 exhibited a slower decline in total Mini-Mental State Examination scores, orientation, registration, and functional status than those with the wild type. A significant interaction between CYP2D6, APOE, and time was found for changes in the Activities of Daily Living Scale; among the ε4 carriers, those with the mutated CYP2D6 exhibited a slower decline on the Activities of Daily Living Scale than those with the wild type | ||
| 520 | |a CONCLUSION: The CYP2D6 and APOE genotypes may modulate the effectiveness of donepezil on cognitive and functional status | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a acetylcholinesterase inhibitors | |
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| 700 | 1 | |a Pigozzo, Sabrina |e verfasserin |4 aut | |
| 700 | 1 | |a De Rui, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Devita, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Girardi, Agostino |e verfasserin |4 aut | |
| 700 | 1 | |a Manzato, Enzo |e verfasserin |4 aut | |
| 700 | 1 | |a Sergi, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Coin, Alessandra |e verfasserin |4 aut | |
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