Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ..
OBJECTIVE: The SARS-CoV-2-infected disease (COVID-19) outbreak is a major threat to human beings. Previous studies mainly focused on Wuhan and typical symptoms. We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province to determine epidemiological, clinical and virological characteristics.
DESIGN: COVID-19 hospital patients were admitted in the Zhejiang province from 17 January 2020 to 8 February 2020. Epidemiological, demographic, clinical, laboratory, management and outcome data of patients with GI symptoms were analysed using multivariate analysis for risk of severe/critical type. Bioinformatics were used to analyse features of SARS-CoV-2 from Zhejiang province.
RESULTS: Among enrolled 651 patients, 74 (11.4%) presented with at least one GI symptom (nausea, vomiting or diarrhoea), average age of 46.14 years, 4-day incubation period and 10.8% had pre-existing liver disease. Of patients with COVID-19 with GI symptoms, 17 (22.97%) and 23 (31.08%) had severe/critical types and family clustering, respectively, significantly higher than those without GI symptoms, 47 (8.14%) and 118 (20.45%). Of patients with COVID-19 with GI symptoms, 29 (39.19%), 23 (31.08%), 8 (10.81%) and 16 (21.62%) had significantly higher rates of fever >38.5°C, fatigue, shortness of breath and headache, respectively. Low-dose glucocorticoids and antibiotics were administered to 14.86% and 41.89% of patients, respectively. Sputum production and increased lactate dehydrogenase/glucose levels were risk factors for severe/critical type. Bioinformatics showed sequence mutation of SARS-CoV-2 with m6A methylation and changed binding capacity with ACE2.
CONCLUSION: We report COVID-19 cases with GI symptoms with novel features outside Wuhan. Attention to patients with COVID-19 with non-classic symptoms should increase to protect health providers.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:69 |
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| Enthalten in: |
Gut - 69(2020), 6 vom: 25. Juni, Seite 1002-1009 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jin, Xi [VerfasserIn] |
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| Links: |
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| Themen: |
Diarrhoea |
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| Anmerkungen: |
Date Completed 13.05.2020 Date Revised 09.03.2021 published: Print-Electronic CommentIn: Gut. 2020 Jul;69(7):1364-1365. - PMID 32312788 Citation Status MEDLINE |
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| doi: |
10.1136/gutjnl-2020-320926 |
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| PPN (Katalog-ID): |
NLM307994155 |
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| 245 | 1 | 0 | |a Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 13.05.2020 | ||
| 500 | |a Date Revised 09.03.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Gut. 2020 Jul;69(7):1364-1365. - PMID 32312788 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a OBJECTIVE: The SARS-CoV-2-infected disease (COVID-19) outbreak is a major threat to human beings. Previous studies mainly focused on Wuhan and typical symptoms. We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province to determine epidemiological, clinical and virological characteristics | ||
| 520 | |a DESIGN: COVID-19 hospital patients were admitted in the Zhejiang province from 17 January 2020 to 8 February 2020. Epidemiological, demographic, clinical, laboratory, management and outcome data of patients with GI symptoms were analysed using multivariate analysis for risk of severe/critical type. Bioinformatics were used to analyse features of SARS-CoV-2 from Zhejiang province | ||
| 520 | |a RESULTS: Among enrolled 651 patients, 74 (11.4%) presented with at least one GI symptom (nausea, vomiting or diarrhoea), average age of 46.14 years, 4-day incubation period and 10.8% had pre-existing liver disease. Of patients with COVID-19 with GI symptoms, 17 (22.97%) and 23 (31.08%) had severe/critical types and family clustering, respectively, significantly higher than those without GI symptoms, 47 (8.14%) and 118 (20.45%). Of patients with COVID-19 with GI symptoms, 29 (39.19%), 23 (31.08%), 8 (10.81%) and 16 (21.62%) had significantly higher rates of fever >38.5°C, fatigue, shortness of breath and headache, respectively. Low-dose glucocorticoids and antibiotics were administered to 14.86% and 41.89% of patients, respectively. Sputum production and increased lactate dehydrogenase/glucose levels were risk factors for severe/critical type. Bioinformatics showed sequence mutation of SARS-CoV-2 with m6A methylation and changed binding capacity with ACE2 | ||
| 520 | |a CONCLUSION: We report COVID-19 cases with GI symptoms with novel features outside Wuhan. Attention to patients with COVID-19 with non-classic symptoms should increase to protect health providers | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a diarrhoea | |
| 650 | 4 | |a infectious disease | |
| 700 | 1 | |a Lian, Jiang-Shan |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Jian-Hua |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Jianguo |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yi-Min |e verfasserin |4 aut | |
| 700 | 1 | |a Hao, Shao-Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Jia, Hong-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Huan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xiao-Li |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Guo-Dong |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Kai-Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiao-Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Gu, Jue-Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Shan-Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Chan-Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Ci-Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Ying-Feng |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Xia |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Xiao-Peng |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Jian-Rong |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Kang-Li |e verfasserin |4 aut | |
| 700 | 1 | |a Ni, Qin |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Cheng-Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Biao |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yong-Tao |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xuan |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Yong-Zheng |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Jun-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Tao, Jing-Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Lang, Guan-Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Xiao-Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Wen-Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Qv, Ting-Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Xiang, Dai-Rong |e verfasserin |4 aut | |
| 700 | 1 | |a Yi, Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Ding |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yanfei |e verfasserin |4 aut | |
| 700 | 1 | |a Ren, Yue |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Yun-Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Lan-Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Sheng, Jifang |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yida |e verfasserin |4 aut | |
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