Scout-multiple reaction monitoring : A liquid chromatography tandem mass spectrometry approach for multi-residue pesticide analysis without time scheduling
Copyright © 2020. Published by Elsevier B.V..
In this work, an innovative method is described for multi-residue pesticide analysis by liquid chromatography coupled to targeted mass spectrometry, called "Scout-MRM, this new acquisition mode relies on the monitoring by either endogenous or spiked Scout compounds, hence fully releasing the monitoring of target molecules from time scheduling. As a proof of concept, a Scout-MRM method was built where 5 transitions groups tracking a total of 191 pesticides where successively triggered under the control of 5 spiked-in deuterated pesticides. As expected from its retention time independency, Scout-MRM demonstrates strong detection robustness towards modifications of gradient parameters, as well as easy method transfer between distinct analytical platforms with nearly 100% recovery after a single run. Finally, Scout-MRM was used for the multi-residue screening and quantification of pesticides in real surface water samples, by applying an external calibration procedure and comparing it with classical scheduled reaction monitoring methods.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:1621 |
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| Enthalten in: |
Journal of chromatography. A - 1621(2020) vom: 21. Juni, Seite 461046 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Salvador, Arnaud [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 23.07.2020 Date Revised 23.07.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.chroma.2020.461046 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM307909735 |
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| 245 | 1 | 0 | |a Scout-multiple reaction monitoring |b A liquid chromatography tandem mass spectrometry approach for multi-residue pesticide analysis without time scheduling |
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| 500 | |a Date Revised 23.07.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020. Published by Elsevier B.V. | ||
| 520 | |a In this work, an innovative method is described for multi-residue pesticide analysis by liquid chromatography coupled to targeted mass spectrometry, called "Scout-MRM, this new acquisition mode relies on the monitoring by either endogenous or spiked Scout compounds, hence fully releasing the monitoring of target molecules from time scheduling. As a proof of concept, a Scout-MRM method was built where 5 transitions groups tracking a total of 191 pesticides where successively triggered under the control of 5 spiked-in deuterated pesticides. As expected from its retention time independency, Scout-MRM demonstrates strong detection robustness towards modifications of gradient parameters, as well as easy method transfer between distinct analytical platforms with nearly 100% recovery after a single run. Finally, Scout-MRM was used for the multi-residue screening and quantification of pesticides in real surface water samples, by applying an external calibration procedure and comparing it with classical scheduled reaction monitoring methods | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a MRM: multiple reaction monitoring | |
| 650 | 4 | |a Multiplexing capability | |
| 650 | 4 | |a Retention time independency | |
| 650 | 4 | |a Scout-MRM | |
| 650 | 4 | |a sMRM: scheduled multiple reaction monitoring | |
| 650 | 7 | |a Pesticide Residues |2 NLM | |
| 700 | 1 | |a Carrière, Romain |e verfasserin |4 aut | |
| 700 | 1 | |a Ayciriex, Sophie |e verfasserin |4 aut | |
| 700 | 1 | |a Margoum, Christelle |e verfasserin |4 aut | |
| 700 | 1 | |a Leblanc, Yves |e verfasserin |4 aut | |
| 700 | 1 | |a Lemoine, Jérôme |e verfasserin |4 aut | |
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