Structure-Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni
Copyright © 2020 American Chemical Society..
We recently reported a series of compounds for a solubility-driven optimization campaign of antitrypanosomal compounds. Extending a parasite-hopping approach to the series, a subset of compounds from this library has been cross-screened for activity against the metazoan flatworm parasite, Schistosoma mansoni. This study reports the identification and preliminary development of several potently bioactive compounds against adult schistosomes, one or more of which represent promising leads for further assessment and optimization.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
ACS medicinal chemistry letters - 11(2020), 3 vom: 12. März, Seite 258-265 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Buskes, Melissa J [VerfasserIn] |
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| Anmerkungen: |
Date Revised 13.11.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acsmedchemlett.9b00455 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM307715043 |
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| 520 | |a Copyright © 2020 American Chemical Society. | ||
| 520 | |a We recently reported a series of compounds for a solubility-driven optimization campaign of antitrypanosomal compounds. Extending a parasite-hopping approach to the series, a subset of compounds from this library has been cross-screened for activity against the metazoan flatworm parasite, Schistosoma mansoni. This study reports the identification and preliminary development of several potently bioactive compounds against adult schistosomes, one or more of which represent promising leads for further assessment and optimization | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Clements, Monica |e verfasserin |4 aut | |
| 700 | 1 | |a Bachovchin, Kelly A |e verfasserin |4 aut | |
| 700 | 1 | |a Jalani, Hitesh B |e verfasserin |4 aut | |
| 700 | 1 | |a Leonard, Allison |e verfasserin |4 aut | |
| 700 | 1 | |a Bag, Seema |e verfasserin |4 aut | |
| 700 | 1 | |a Klug, Dana M |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, Baljinder |e verfasserin |4 aut | |
| 700 | 1 | |a Campbell, Robert F |e verfasserin |4 aut | |
| 700 | 1 | |a Sciotti, Richard J |e verfasserin |4 aut | |
| 700 | 1 | |a El-Sakkary, Nelly |e verfasserin |4 aut | |
| 700 | 1 | |a Caffrey, Conor R |e verfasserin |4 aut | |
| 700 | 1 | |a Pollastri, Michael P |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrins, Lori |e verfasserin |4 aut | |
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