Preparation of Hyaluronic Acid-Based Nanoparticles for Macrophage-Targeted MicroRNA Delivery and Transfection
Skewing the macrophage polarity to achieve a favorable phenotype is a recently investigated therapeutic strategy in multiple disease/dysfunctional conditions such as inflammation, tumors, autoimmune disorders, and tissue repairs. However, delivering the therapeutic agent specifically to the macrophages has been a challenge in this field. Here, we describe the synthesis of hyaluronic acid (HA)-based nanoparticles for targeting CD44 receptors on the macrophages. The HA backbone is modified with cationic polyethyleneimine (PEI) for efficient encapsulation of microRNA into the self-assembling nanoparticles for targeted delivery to macrophages.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2118 |
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| Enthalten in: |
Methods in molecular biology (Clifton, N.J.) - 2118(2020) vom: 09., Seite 99-110 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Parayath, Neha N [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 29.01.2021 Date Revised 29.01.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1007/978-1-0716-0319-2_7 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM307412830 |
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| 520 | |a Skewing the macrophage polarity to achieve a favorable phenotype is a recently investigated therapeutic strategy in multiple disease/dysfunctional conditions such as inflammation, tumors, autoimmune disorders, and tissue repairs. However, delivering the therapeutic agent specifically to the macrophages has been a challenge in this field. Here, we describe the synthesis of hyaluronic acid (HA)-based nanoparticles for targeting CD44 receptors on the macrophages. The HA backbone is modified with cationic polyethyleneimine (PEI) for efficient encapsulation of microRNA into the self-assembling nanoparticles for targeted delivery to macrophages | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a CD44 | |
| 650 | 4 | |a Hyaluronic acid nanoparticles | |
| 650 | 4 | |a M1 and M2 polarization | |
| 650 | 4 | |a Macrophages | |
| 650 | 4 | |a MicroRNA-125b | |
| 650 | 4 | |a Poly(ethyleneimine) | |
| 650 | 4 | |a Targeted delivery | |
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| 650 | 7 | |a Hyaluronan Receptors |2 NLM | |
| 650 | 7 | |a MicroRNAs |2 NLM | |
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| 650 | 7 | |a Hyaluronic Acid |2 NLM | |
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| 700 | 1 | |a Amiji, Mansoor M |e verfasserin |4 aut | |
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