Impact of Postprandial Hypoglycemia on Weight Loss After Bariatric Surgery
INTRODUCTION: Postprandial hypoglycemia (PPHG) is a well-known complication after bariatric surgery (BS). However, it is not known whether PPHG affects weight loss after BS.
AIMS: To assess the impact of PPHG on weight loss after BS in subjects without and with type 2 diabetes mellitus (T2D).
METHODS: Data from 338 subjects who had undergone gastric bypass (RYGB) or sleeve gastrectomy (LSG) and were followed up for at least 2 years were analyzed. At each follow-up visit, the patient's anthropometric and biochemical characteristics were recorded and the Edinburgh Questionnaire was performed to evaluate the presence of PPHG symptoms.
RESULTS: Before surgery: younger age and lower BMI predicted PPHG after BS (p = 0.02 and p = 0.0008, respectively). Also, the baseline OGTT indicated that subjects who developed PPHG had an earlier glucose peak and more often had low glucose levels at 2 h compared with the no-PPHG group (p = 0.03 and p = 0.004, respectively). After surgery: Mild-to-moderate PPHG occurred equally after RYGB and LSG (38% vs 25%, p = ns when accounting for confounders), and in T2D who achieved remission and those who did not (29.5% vs 28.6%, ns). At the 2-year follow-up, occurrence of PPHG was independently associated with smaller weight loss (p = 0.0006).
CONCLUSIONS: Mild-to-moderate PPHG is a frequent complication after bariatric surgery and results in smaller weight loss after 2 years. Age, baseline BMI, and an earlier glucose peak during OGTT predict PPHG after bariatric surgery.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Obesity surgery - 30(2020), 6 vom: 04. Juni, Seite 2266-2273 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rebelos, Eleni [VerfasserIn] |
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| Links: |
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| Themen: |
Bariatric surgery |
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| Anmerkungen: |
Date Completed 14.04.2021 Date Revised 03.11.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1007/s11695-020-04465-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM307246353 |
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| 500 | |a Date Revised 03.11.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: Postprandial hypoglycemia (PPHG) is a well-known complication after bariatric surgery (BS). However, it is not known whether PPHG affects weight loss after BS | ||
| 520 | |a AIMS: To assess the impact of PPHG on weight loss after BS in subjects without and with type 2 diabetes mellitus (T2D) | ||
| 520 | |a METHODS: Data from 338 subjects who had undergone gastric bypass (RYGB) or sleeve gastrectomy (LSG) and were followed up for at least 2 years were analyzed. At each follow-up visit, the patient's anthropometric and biochemical characteristics were recorded and the Edinburgh Questionnaire was performed to evaluate the presence of PPHG symptoms | ||
| 520 | |a RESULTS: Before surgery: younger age and lower BMI predicted PPHG after BS (p = 0.02 and p = 0.0008, respectively). Also, the baseline OGTT indicated that subjects who developed PPHG had an earlier glucose peak and more often had low glucose levels at 2 h compared with the no-PPHG group (p = 0.03 and p = 0.004, respectively). After surgery: Mild-to-moderate PPHG occurred equally after RYGB and LSG (38% vs 25%, p = ns when accounting for confounders), and in T2D who achieved remission and those who did not (29.5% vs 28.6%, ns). At the 2-year follow-up, occurrence of PPHG was independently associated with smaller weight loss (p = 0.0006) | ||
| 520 | |a CONCLUSIONS: Mild-to-moderate PPHG is a frequent complication after bariatric surgery and results in smaller weight loss after 2 years. Age, baseline BMI, and an earlier glucose peak during OGTT predict PPHG after bariatric surgery | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bariatric surgery | |
| 650 | 4 | |a Postprandial hypoglycemia | |
| 650 | 4 | |a RYGB | |
| 650 | 4 | |a Sleeve gastrectomy | |
| 650 | 4 | |a Weight loss | |
| 700 | 1 | |a Moriconi, Diego |e verfasserin |4 aut | |
| 700 | 1 | |a Scalese, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Denoth, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Molinaro, Sabrina |e verfasserin |4 aut | |
| 700 | 1 | |a Siciliano, Valeria |e verfasserin |4 aut | |
| 700 | 1 | |a Anselmino, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Taddei, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrannini, Ele |e verfasserin |4 aut | |
| 700 | 1 | |a Nannipieri, Monica |e verfasserin |4 aut | |
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