Functional modeling of pedaling kinematics for the Stroke patients

Understanding deficits in motor control through the analysis of pedaling biomechanics plays a key role in the treatment of stroke patients. A thorough study of the impact of different exercise patterns and workloads on the change between pre- and post-treatment movement patterns in the patients is therefore of utmost importance to the clinicians. The objective of this study was to analyze the difference between pre- and post-treatment pedaling torques when the patients are subject to different exercise groups with varying workloads. The effects of affected vs unaffected side along with the covariates age and BMI have also been accounted for in this work. Two different three-way ANOVA-based approaches have been implemented here. In the first approach, a random projection-based ANOVA technique has been performed treating the pedaling torques as functional response, whereas the second approach utilizes distance measures to summarize the difference between pre- and post-treatment torques and perform nonparametric tests on it. Bayesian bootstrap has been used here to perform tests on the median distance. A group of stroke patients have been studied in the Cleveland Clinic categorizing them into different exercise groups and workload patterns. The data obtained have been analyzed with the aforementioned techniques, and the results have been reported here. These techniques turn out to be promising and will help clinicians recommend personalized treatment to stroke patients for optimal results.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:30

Enthalten in:

Journal of biopharmaceutical statistics - 30(2020), 4 vom: 03. Juli, Seite 674-688

Sprache:

Englisch

Beteiligte Personen:

Chakraborty, Sounak [VerfasserIn]
Dey, Tanujit [VerfasserIn]
Mukherjee, Anish [VerfasserIn]
Alberts, Jay L [VerfasserIn]
Linder, Susan M [VerfasserIn]

Links:

Volltext

Themen:

Bayesian bootstrap
Comparative Study
Fréchet distance
Functional ANOVA
Journal Article
Nonparametric tests
Personalized treatment
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 02.08.2021

Date Revised 02.08.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1080/10543406.2020.1730872

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM307204723