Inner ear delivery : Challenges and opportunities
© 2019 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society..
OBJECTIVES: The treatment of inner ear disorders remains challenging due to anatomic barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent advances and strategies for overcoming these barriers and to discuss promising future avenues for investigation.
DATA SOURCES: The databases used were PubMed, EMBASE, and Web of Science.
RESULTS: Although some studies aimed to improve systemic delivery using nanoparticle systems, the majority enhanced local delivery using hydrogels, nanoparticles, and microneedles. Developments in direct intracochlear delivery include intracochlear injection and intracochlear implants.
CONCLUSIONS: In the absence of a systemic drug that targets only the inner ear, the best alternative is local delivery that harnesses a combination of new strategies to overcome anatomic barriers. The combination of microneedle technology with hydrogel and nanoparticle delivery is a promising area for future investigation.
LEVEL OF EVIDENCE: NA.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
Laryngoscope investigative otolaryngology - 5(2020), 1 vom: 19. Feb., Seite 122-131 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Szeto, Betsy [VerfasserIn] |
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| Links: |
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| Themen: |
Inner ear disorders |
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| Anmerkungen: |
Date Revised 28.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1002/lio2.336 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM307197751 |
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| 500 | |a Date Revised 28.03.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2019 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society. | ||
| 520 | |a OBJECTIVES: The treatment of inner ear disorders remains challenging due to anatomic barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent advances and strategies for overcoming these barriers and to discuss promising future avenues for investigation | ||
| 520 | |a DATA SOURCES: The databases used were PubMed, EMBASE, and Web of Science | ||
| 520 | |a RESULTS: Although some studies aimed to improve systemic delivery using nanoparticle systems, the majority enhanced local delivery using hydrogels, nanoparticles, and microneedles. Developments in direct intracochlear delivery include intracochlear injection and intracochlear implants | ||
| 520 | |a CONCLUSIONS: In the absence of a systemic drug that targets only the inner ear, the best alternative is local delivery that harnesses a combination of new strategies to overcome anatomic barriers. The combination of microneedle technology with hydrogel and nanoparticle delivery is a promising area for future investigation | ||
| 520 | |a LEVEL OF EVIDENCE: NA | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a intracochlear delivery | |
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| 650 | 4 | |a nanoparticles | |
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| 700 | 1 | |a Valentini, Chris |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Michelle |e verfasserin |4 aut | |
| 700 | 1 | |a Kysar, Jeffrey W |e verfasserin |4 aut | |
| 700 | 1 | |a Lalwani, Anil K |e verfasserin |4 aut | |
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