Evaluation of chromosomal abnormalities and Y-chromosome microdeletions in 1696 Turkish cases with primary male infertility : A single-center study
OBJECTIVE: The aim of this study was to determine the frequencies of chromosomal abnormalities and Y-chromosome microdeletions in Turkish cases with primary male infertility in a single center.
MATERIAL AND METHODS: Chromosomal abnormalities and Y-chromosome microdeletions were investigated in 1696 cases with primary male infertility between 2012 and 2017. Karyotype analyzes and Y-chromosome microdeletions analyzes [azoospermia factor (AZF) regions] were performed in all cases by using standard cytogenetic methods and the multiplex polymerase chain reaction method, respectively.
RESULTS: Chromosomal abnormalities were found in 142 cases (8.4%; 142/1696). Y-chromosome microdeletions were detected in 46 cases (2.7%; 46/1696). Y-chromosome microdeletions in the AZFc region were found in 20 of 46 cases (43%).
CONCLUSION: This study is one of the few were a large number of cases was studied in Turkey. It indicates that cytogenetic and Y-chromosome microdeletion studies should be conducted in cases with primary male infertility prior to selecting assisted reproductive techniques.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
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| Enthalten in: |
Turkish journal of urology - 46(2020), 2 vom: 03. März, Seite 95-100 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Özdemir, Taha Reşid [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 28.09.2020 published: Electronic-Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.5152/tud.2019.19156 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM307173453 |
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| 100 | 1 | |a Özdemir, Taha Reşid |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evaluation of chromosomal abnormalities and Y-chromosome microdeletions in 1696 Turkish cases with primary male infertility |b A single-center study |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Revised 28.09.2020 | ||
| 500 | |a published: Electronic-Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a OBJECTIVE: The aim of this study was to determine the frequencies of chromosomal abnormalities and Y-chromosome microdeletions in Turkish cases with primary male infertility in a single center | ||
| 520 | |a MATERIAL AND METHODS: Chromosomal abnormalities and Y-chromosome microdeletions were investigated in 1696 cases with primary male infertility between 2012 and 2017. Karyotype analyzes and Y-chromosome microdeletions analyzes [azoospermia factor (AZF) regions] were performed in all cases by using standard cytogenetic methods and the multiplex polymerase chain reaction method, respectively | ||
| 520 | |a RESULTS: Chromosomal abnormalities were found in 142 cases (8.4%; 142/1696). Y-chromosome microdeletions were detected in 46 cases (2.7%; 46/1696). Y-chromosome microdeletions in the AZFc region were found in 20 of 46 cases (43%) | ||
| 520 | |a CONCLUSION: This study is one of the few were a large number of cases was studied in Turkey. It indicates that cytogenetic and Y-chromosome microdeletion studies should be conducted in cases with primary male infertility prior to selecting assisted reproductive techniques | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Özyılmaz, Berk |e verfasserin |4 aut | |
| 700 | 1 | |a Çakmak, Özgür |e verfasserin |4 aut | |
| 700 | 1 | |a Kaya, Özge Özer |e verfasserin |4 aut | |
| 700 | 1 | |a Köse, Can |e verfasserin |4 aut | |
| 700 | 1 | |a Kırbıyık, Özgür |e verfasserin |4 aut | |
| 700 | 1 | |a Keskin, Mehmet Zeynel |e verfasserin |4 aut | |
| 700 | 1 | |a Koç, Altuğ |e verfasserin |4 aut | |
| 700 | 1 | |a Zeyrek, Tuğba |e verfasserin |4 aut | |
| 700 | 1 | |a Kutbay, Yaşar Bekir |e verfasserin |4 aut | |
| 700 | 1 | |a Erdoğan, Kadri Murat |e verfasserin |4 aut | |
| 700 | 1 | |a Güvenç, Merve Saka |e verfasserin |4 aut | |
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