Influence of Benz[a]anthracene on Bone Metabolism and on Liver Metabolism in Nibbler Fish, Girella punctata
It has been reported that spinal deformity was induced in developing fish by the addition of polycyclic aromatic hydrocarbons (PAHs). To examine the mechanism of the disruption of fish bone metabolism, the effect of benz[a]anthracene (BaA), a kind of PAH, on plasma calcium, inorganic phosphorus, osteoblasts, and osteoclasts was investigated in this study. We also measured several plasma components to analyze the toxicity of BaA on other metabolisms. BaA (1 or 10 ng/g body weight) was intraperitoneally injected (four times) into nibbler fish during breeding, for 10 days, and it was indicated, for the first time, that injecting high doses of BaA to nibbler fish induced both hypocalcemia and hypophosphatemia. Furthermore, in the scales of nibbler fish treated with high doses of BaA, both osteoclastic and osteoblastic marker messengerRNA (mRNA) expressions decreased. These results are a cause of disruption of bone metabolism and, perhaps, the induction of spinal deformities. In addition, we found that total protein, metabolic enzymes in the liver, total cholesterol, free cholesterol, and high-density lipoprotein cholesterol levels significantly decreased in BaA-injected fish. These results indicate that BaA may affect liver diseases and emphasize the importance of prevention of aquatic PAH pollution.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
|---|---|
| Enthalten in: |
International journal of environmental research and public health - 17(2020), 4 vom: 21. Feb. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Zanaty, Mohamed I [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 17.09.2020 Date Revised 17.09.2020 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.3390/ijerph17041391 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM306906538 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM306906538 | ||
| 003 | DE-627 | ||
| 005 | 20231225124411.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/ijerph17041391 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1022.xml |
| 035 | |a (DE-627)NLM306906538 | ||
| 035 | |a (NLM)32098178 | ||
| 035 | |a (PII)E1391 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Zanaty, Mohamed I |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Influence of Benz[a]anthracene on Bone Metabolism and on Liver Metabolism in Nibbler Fish, Girella punctata |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 17.09.2020 | ||
| 500 | |a Date Revised 17.09.2020 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a It has been reported that spinal deformity was induced in developing fish by the addition of polycyclic aromatic hydrocarbons (PAHs). To examine the mechanism of the disruption of fish bone metabolism, the effect of benz[a]anthracene (BaA), a kind of PAH, on plasma calcium, inorganic phosphorus, osteoblasts, and osteoclasts was investigated in this study. We also measured several plasma components to analyze the toxicity of BaA on other metabolisms. BaA (1 or 10 ng/g body weight) was intraperitoneally injected (four times) into nibbler fish during breeding, for 10 days, and it was indicated, for the first time, that injecting high doses of BaA to nibbler fish induced both hypocalcemia and hypophosphatemia. Furthermore, in the scales of nibbler fish treated with high doses of BaA, both osteoclastic and osteoblastic marker messengerRNA (mRNA) expressions decreased. These results are a cause of disruption of bone metabolism and, perhaps, the induction of spinal deformities. In addition, we found that total protein, metabolic enzymes in the liver, total cholesterol, free cholesterol, and high-density lipoprotein cholesterol levels significantly decreased in BaA-injected fish. These results indicate that BaA may affect liver diseases and emphasize the importance of prevention of aquatic PAH pollution | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a benz[a]anthracene | |
| 650 | 4 | |a calcium | |
| 650 | 4 | |a fish scales | |
| 650 | 4 | |a inorganic phosphorus | |
| 650 | 4 | |a liver metabolism | |
| 650 | 4 | |a marine fish | |
| 650 | 4 | |a osteoblasts | |
| 650 | 4 | |a osteoclasts | |
| 650 | 7 | |a Anthracenes |2 NLM | |
| 650 | 7 | |a Polycyclic Aromatic Hydrocarbons |2 NLM | |
| 650 | 7 | |a Water Pollutants, Chemical |2 NLM | |
| 700 | 1 | |a Sawada, Niina |e verfasserin |4 aut | |
| 700 | 1 | |a Kitani, Yoichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Nassar, Hossam F |e verfasserin |4 aut | |
| 700 | 1 | |a Mahmoud, Hamada M |e verfasserin |4 aut | |
| 700 | 1 | |a Hayakawa, Kazuichi |e verfasserin |4 aut | |
| 700 | 1 | |a Sekiguchi, Toshio |e verfasserin |4 aut | |
| 700 | 1 | |a Ogiso, Shouzo |e verfasserin |4 aut | |
| 700 | 1 | |a Tabuchi, Yoshiaki |e verfasserin |4 aut | |
| 700 | 1 | |a Urata, Makoto |e verfasserin |4 aut | |
| 700 | 1 | |a Matsubara, Hajime |e verfasserin |4 aut | |
| 700 | 1 | |a Takeuchi, Yutaka |e verfasserin |4 aut | |
| 700 | 1 | |a Hattori, Atsuhiko |e verfasserin |4 aut | |
| 700 | 1 | |a Srivastav, Ajai K |e verfasserin |4 aut | |
| 700 | 1 | |a Amornsakun, Thumronk |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Nobuo |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of environmental research and public health |d 2004 |g 17(2020), 4 vom: 21. Feb. |w (DE-627)NLM162777434 |x 1660-4601 |7 nnns |
| 773 | 1 | 8 | |g volume:17 |g year:2020 |g number:4 |g day:21 |g month:02 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/ijerph17041391 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 17 |j 2020 |e 4 |b 21 |c 02 | ||