Presepsin:albumin ratio and C-reactive protein:albumin ratio as novel sepsis-based prognostic scores : A retrospective study
OBJECTIVE: To investigate the prognostic value of the presepsin:albumin ratio and C‑reactive protein:albumin ratio in patients with sepsis in the intensive care unit (ICU).
METHODS: A total of 228 (129 males and 99 females) patients with newly diagnosed sepsis were included in the study. The relationship between the C‑reactive protein:albumin ratio, presepsin:albumin ratio, clinicopathologic parameters, and overall survival were investigated. The associations between C‑reactive protein:albumin ratio and presepsin:albumin ratio were evaluated alongside other inflammation-based prognostic scores such as quick Sepsis Related Organ Failure Assessment (qSOFA).
RESULTS: The presepsin:albumin ratio was significantly higher in non-survivors (p < 0.01). Patients with a high presepsin:albumin ratio had worse overall survival compared with patients with high C‑reactive protein:albumin ratio levels (p < 0.001).
CONCLUSION: Presepsin and presepsin:albumin ratio are markers of adverse prognosis in patients with sepsis and are superior to C‑reactive protein and C‑reactive protein:albumin ratio for this purpose. Presepsin:albumin ratio may be a novel marker of poor prognosis in patients with sepsis in intensive care units.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:132 |
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| Enthalten in: |
Wiener klinische Wochenschrift - 132(2020), 7-8 vom: 14. Apr., Seite 182-187 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kaplan, Mustafa [VerfasserIn] |
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| Links: |
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| Themen: |
9007-41-4 |
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| Anmerkungen: |
Date Completed 17.11.2020 Date Revised 17.11.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00508-020-01618-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM306548526 |
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| 100 | 1 | |a Kaplan, Mustafa |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Presepsin:albumin ratio and C-reactive protein:albumin ratio as novel sepsis-based prognostic scores |b A retrospective study |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 17.11.2020 | ||
| 500 | |a Date Revised 17.11.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To investigate the prognostic value of the presepsin:albumin ratio and C‑reactive protein:albumin ratio in patients with sepsis in the intensive care unit (ICU) | ||
| 520 | |a METHODS: A total of 228 (129 males and 99 females) patients with newly diagnosed sepsis were included in the study. The relationship between the C‑reactive protein:albumin ratio, presepsin:albumin ratio, clinicopathologic parameters, and overall survival were investigated. The associations between C‑reactive protein:albumin ratio and presepsin:albumin ratio were evaluated alongside other inflammation-based prognostic scores such as quick Sepsis Related Organ Failure Assessment (qSOFA) | ||
| 520 | |a RESULTS: The presepsin:albumin ratio was significantly higher in non-survivors (p < 0.01). Patients with a high presepsin:albumin ratio had worse overall survival compared with patients with high C‑reactive protein:albumin ratio levels (p < 0.001) | ||
| 520 | |a CONCLUSION: Presepsin and presepsin:albumin ratio are markers of adverse prognosis in patients with sepsis and are superior to C‑reactive protein and C‑reactive protein:albumin ratio for this purpose. Presepsin:albumin ratio may be a novel marker of poor prognosis in patients with sepsis in intensive care units | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Albumin | |
| 650 | 4 | |a C‑reactive protein | |
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| 650 | 4 | |a Sepsis | |
| 650 | 7 | |a Albumins |2 NLM | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Lipopolysaccharide Receptors |2 NLM | |
| 650 | 7 | |a Peptide Fragments |2 NLM | |
| 650 | 7 | |a presepsin protein, human |2 NLM | |
| 650 | 7 | |a C-Reactive Protein |2 NLM | |
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| 700 | 1 | |a Tanoglu, Alpaslan |e verfasserin |4 aut | |
| 700 | 1 | |a Cakir Guney, Basak |e verfasserin |4 aut | |
| 700 | 1 | |a Onal Tastan, Yesim |e verfasserin |4 aut | |
| 700 | 1 | |a Bicer, Hatice Selcen |e verfasserin |4 aut | |
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