Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea : the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR
© 2020 The Korean Academy of Medical Sciences..
Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.
| Errataetall: |
CommentIn: J Korean Med Sci. 2020 Feb 24;35(7):e88. - PMID 32080992 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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| Enthalten in: |
Journal of Korean medical science - 35(2020), 6 vom: 17. Feb., Seite e79 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lim, Jaegyun [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 16.03.2020 Date Revised 07.12.2022 published: Electronic CommentIn: J Korean Med Sci. 2020 Feb 24;35(7):e88. - PMID 32080992 Citation Status MEDLINE |
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| doi: |
10.3346/jkms.2020.35.e79 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM306505940 |
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| 520 | |a Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Coronavirus | |
| 650 | 4 | |a Pneumonia | |
| 650 | 4 | |a Real-Time Reverse-Transcriptase Polymerase Chain Reaction | |
| 650 | 4 | |a Tertiary Infection | |
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| 650 | 7 | |a Covid-19 aAPC vaccine |2 NLM | |
| 650 | 7 | |a Cytochrome P-450 CYP3A Inhibitors |2 NLM | |
| 650 | 7 | |a Drug Combinations |2 NLM | |
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| 700 | 1 | |a Jeon, Seunghyun |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Hyun Young |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Moon Jung |e verfasserin |4 aut | |
| 700 | 1 | |a Seong, Yu Min |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Wang Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Choe, Kang Won |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Yu Min |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Baeckseung |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Sang Joon |e verfasserin |4 aut | |
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