The feasibility of locating the affected bone of BRONJ with indocyanine green
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved..
The morbidity of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is also increasing with the use of bisphosphonates (BPs). Removing affected bone accurately is the most effective treatment. This study aimed to explore the feasibility of Indocyanine green (ICG)-based Near-Infrared fluorescence (NIF) imaging to remove BRONJ affected bone. Firstly, the rat model of BRONJ was constructed. And 5 mg/kg ICG were injected via tail vein, after 12 hr, the affected and healthy bone were dissected for ICG-based NIF imaging and quantification detection of fluorescence intensity. Finally, all the bone samples were sent for further pathological examination. All the affected bone tissues in rat BRONJ model were fluorescence developed with ICG. And the fluorescence developed regions were further confirmed as affected bone tissues with pathological examination. The fluorescence intensity in affected bone tissues, adjacent, and opposite bone tissues was 1.93*107 ± 2.08*106, 1.19*106 ± 2.33*105, and 1.24*106 ± 1.57*105, respectively (p < .05). Conclusions It was feasible that the extent of affected bone in rat model with BRONJ could be estimated intraoperative via ICG-based NIF imaging. This novel approach would become an auxiliary method in the treatment of patients with BRONJ in the future.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Oral diseases - 26(2020), 5 vom: 02. Juli, Seite 1086-1089 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Xia, Cheng-Wan [VerfasserIn] |
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| Links: |
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| Themen: |
Affected bone tissues |
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| Anmerkungen: |
Date Completed 28.10.2020 Date Revised 28.10.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/odi.13299 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM306259389 |
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| 245 | 1 | 4 | |a The feasibility of locating the affected bone of BRONJ with indocyanine green |
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| 520 | |a © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved. | ||
| 520 | |a The morbidity of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is also increasing with the use of bisphosphonates (BPs). Removing affected bone accurately is the most effective treatment. This study aimed to explore the feasibility of Indocyanine green (ICG)-based Near-Infrared fluorescence (NIF) imaging to remove BRONJ affected bone. Firstly, the rat model of BRONJ was constructed. And 5 mg/kg ICG were injected via tail vein, after 12 hr, the affected and healthy bone were dissected for ICG-based NIF imaging and quantification detection of fluorescence intensity. Finally, all the bone samples were sent for further pathological examination. All the affected bone tissues in rat BRONJ model were fluorescence developed with ICG. And the fluorescence developed regions were further confirmed as affected bone tissues with pathological examination. The fluorescence intensity in affected bone tissues, adjacent, and opposite bone tissues was 1.93*107 ± 2.08*106, 1.19*106 ± 2.33*105, and 1.24*106 ± 1.57*105, respectively (p < .05). Conclusions It was feasible that the extent of affected bone in rat model with BRONJ could be estimated intraoperative via ICG-based NIF imaging. This novel approach would become an auxiliary method in the treatment of patients with BRONJ in the future | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a affected bone tissues | |
| 650 | 4 | |a indocyanine green | |
| 650 | 4 | |a near-infrared fluorescence imaging | |
| 650 | 7 | |a Bone Density Conservation Agents |2 NLM | |
| 650 | 7 | |a Diphosphonates |2 NLM | |
| 650 | 7 | |a Indocyanine Green |2 NLM | |
| 650 | 7 | |a IX6J1063HV |2 NLM | |
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| 700 | 1 | |a Fan, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Xiao, Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Pu, Yumei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yu-Xin |e verfasserin |4 aut | |
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