Genetic Variations of VEGFA Gene Are Associated With Infiltration of Adjacent Tissues and the Clinical Outcome of Patients With Nasopharyngeal Carcinoma
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved..
BACKGROUND/AIM: The aim of the present study was to investigate the clinical significance of 7 single nucleotide polymorphisms (SNPs) of vascular endothelial growth factor A (VEGFA), endothelin receptor type A (EDNRA), nibrin (NBS1) and Fas cell surface death receptor (FAS) genes in patients with nasopharyngeal carcinoma (NPC).
PATIENTS AND METHODS: Genomic DNA was extracted from the peripheral blood specimens of 60 patients. Genotyping of 4 VEGFA polymorphisms, namely VEGFA -1154 G/A (rs1570360), -2578 A/C (rs699947), -1498 C/T (rs833061) and +936 C/T (rs3025039), as well as EDNRA SNP p.His323 (rs5333), NBS1 p.E185Q (rs1805794) and FAS -671 A/G (rs1800682) was performed by using Sanger sequencing.
RESULTS: The VEGFA +936 CC genotype was more frequent in tumors with bilateral infiltration of pterygoid plates compared to those with ipsilateral (76.9% vs. 69.6%, p=0.008) and no infiltration of pterygoid plates (76.9% vs. 68.8%, p=0.023). VEGFA -2578, VEGFA -1154 and VEGFA +936 were significantly associated with infiltration to the pterygoid processes (p=0.011, p=0.041 and p=0.032, respectively). EDNRA H323H TT genotype was marginally associated with infiltration to the ipsilateral medial pterygoid muscles (p=0.045). A trend towards longer overall survival was observed for VEGFA -2578 CC as compared to AC (HR=0.24, p=0.060).
CONCLUSION: The studied VEGFA SNPs seem to be associated with the local extension of the NPC and maybe with the clinical outcome of this patient group.
| Errataetall: |
ErratumIn: Anticancer Res. 2020 Jun;40(6):3589. - PMID 32487662 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
|---|---|
| Enthalten in: |
Anticancer research - 40(2020), 2 vom: 23. Feb., Seite 677-688 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Psoma, Elizabeth [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
CT |
|---|
| Anmerkungen: |
Date Completed 25.02.2020 Date Revised 25.02.2020 published: Print ErratumIn: Anticancer Res. 2020 Jun;40(6):3589. - PMID 32487662 Citation Status MEDLINE |
|---|
| doi: |
10.21873/anticanres.13997 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM306104334 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM306104334 | ||
| 003 | DE-627 | ||
| 005 | 20231225122630.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.21873/anticanres.13997 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1020.xml |
| 035 | |a (DE-627)NLM306104334 | ||
| 035 | |a (NLM)32014908 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Psoma, Elizabeth |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Genetic Variations of VEGFA Gene Are Associated With Infiltration of Adjacent Tissues and the Clinical Outcome of Patients With Nasopharyngeal Carcinoma |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 25.02.2020 | ||
| 500 | |a Date Revised 25.02.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a ErratumIn: Anticancer Res. 2020 Jun;40(6):3589. - PMID 32487662 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. | ||
| 520 | |a BACKGROUND/AIM: The aim of the present study was to investigate the clinical significance of 7 single nucleotide polymorphisms (SNPs) of vascular endothelial growth factor A (VEGFA), endothelin receptor type A (EDNRA), nibrin (NBS1) and Fas cell surface death receptor (FAS) genes in patients with nasopharyngeal carcinoma (NPC) | ||
| 520 | |a PATIENTS AND METHODS: Genomic DNA was extracted from the peripheral blood specimens of 60 patients. Genotyping of 4 VEGFA polymorphisms, namely VEGFA -1154 G/A (rs1570360), -2578 A/C (rs699947), -1498 C/T (rs833061) and +936 C/T (rs3025039), as well as EDNRA SNP p.His323 (rs5333), NBS1 p.E185Q (rs1805794) and FAS -671 A/G (rs1800682) was performed by using Sanger sequencing | ||
| 520 | |a RESULTS: The VEGFA +936 CC genotype was more frequent in tumors with bilateral infiltration of pterygoid plates compared to those with ipsilateral (76.9% vs. 69.6%, p=0.008) and no infiltration of pterygoid plates (76.9% vs. 68.8%, p=0.023). VEGFA -2578, VEGFA -1154 and VEGFA +936 were significantly associated with infiltration to the pterygoid processes (p=0.011, p=0.041 and p=0.032, respectively). EDNRA H323H TT genotype was marginally associated with infiltration to the ipsilateral medial pterygoid muscles (p=0.045). A trend towards longer overall survival was observed for VEGFA -2578 CC as compared to AC (HR=0.24, p=0.060) | ||
| 520 | |a CONCLUSION: The studied VEGFA SNPs seem to be associated with the local extension of the NPC and maybe with the clinical outcome of this patient group | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CT | |
| 650 | 4 | |a EDNRA NBS1 | |
| 650 | 4 | |a FAS | |
| 650 | 4 | |a MRI | |
| 650 | 4 | |a Nasopharyngeal | |
| 650 | 4 | |a SNPs | |
| 650 | 4 | |a VEGFA | |
| 650 | 4 | |a cancer | |
| 650 | 4 | |a genotype | |
| 650 | 4 | |a polymorphism | |
| 650 | 4 | |a variations | |
| 650 | 7 | |a VEGFA protein, human |2 NLM | |
| 650 | 7 | |a Vascular Endothelial Growth Factor A |2 NLM | |
| 700 | 1 | |a Koliou, Georgia-Angeliki |e verfasserin |4 aut | |
| 700 | 1 | |a Dimitrakopoulos, Foteinos-Ioannis |e verfasserin |4 aut | |
| 700 | 1 | |a Papadopoulou, Kyriaki |e verfasserin |4 aut | |
| 700 | 1 | |a Rontogianni, Dimitra |e verfasserin |4 aut | |
| 700 | 1 | |a Bobos, Mattheos |e verfasserin |4 aut | |
| 700 | 1 | |a Visvikis, Anastasios |e verfasserin |4 aut | |
| 700 | 1 | |a Kosmidis, Paris A |e verfasserin |4 aut | |
| 700 | 1 | |a Fountzilas, George |e verfasserin |4 aut | |
| 700 | 1 | |a Constantinidis, Jannis |e verfasserin |4 aut | |
| 700 | 1 | |a Kalogera-Fountzila, Anna |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Anticancer research |d 1987 |g 40(2020), 2 vom: 23. Feb., Seite 677-688 |w (DE-627)NLM012601454 |x 1791-7530 |7 nnns |
| 773 | 1 | 8 | |g volume:40 |g year:2020 |g number:2 |g day:23 |g month:02 |g pages:677-688 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.21873/anticanres.13997 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 40 |j 2020 |e 2 |b 23 |c 02 |h 677-688 | ||