Hepatitis B Surface Antigen Seropositive Men in Serodiscordant Couples : Effects on the Assisted Reproductive Outcomes
Copyright © 2021 Korean Society for Sexual Medicine and Andrology..
PURPOSE: To evaluate the influence of hepatitis B virus (HBV) infection in men of serodiscordant couples on the reproductive outcomes.
MATERIALS AND METHODS: A total of 134 infertile couples were included in this retrospective single-center cohort study. Sixty-six couples had hepatitis B surface antigen (HBsAg)-seropositive men and seronegative partners, while 68 couples were controls with both seronegative men and women. Overall, 134 fresh in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments were performed. As the main outcome measures, on the day of the fresh IVF/ICSI cycle, we assessed seminal parameters Before and after sperm preparation techniques. Two-pronuclear (2PN) fertilization, 1-2-3PN fertilization, cleavage, miscarriage, pregnancy and live birth rates were collected.
RESULTS: No significant differences were found between groups in terms of oocytes retrieved, oocytes injected and embryos obtained (p=0.64, p=0.97, and p=0.40, respectively). The 2PN fertilization rate (FR) was comparable among groups (p=0.51). The 1-2-3PN FR was significantly lower in the HBsAg group than in the control group (66.6% vs. 69.7%, respectively). The clinical pregnancy per cycle, implantation, miscarriage and live birth rate were comparable between the HBsAg group and the control group. The median sperm concentration/ml and total sperm count, measured at baseline and after sperm preparation, was comparable between groups (p>0.05). There was a trend toward significant lower progressive motility (35.0% vs. 55.0%; p<0.05) in the HBsAg group at baseline and after sperm preparation (p<0.05).
CONCLUSIONS: HBV infected men have the same chance to became father, compared to seronegative patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
The world journal of men's health - 39(2021), 1 vom: 04. Jan., Seite 99-106 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cito, Gianmartin [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-hepatitis B antigens |
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| Anmerkungen: |
Date Revised 05.01.2021 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.5534/wjmh.190121 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM306049392 |
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| 245 | 1 | 0 | |a Hepatitis B Surface Antigen Seropositive Men in Serodiscordant Couples |b Effects on the Assisted Reproductive Outcomes |
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| 500 | |a Date Revised 05.01.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2021 Korean Society for Sexual Medicine and Andrology. | ||
| 520 | |a PURPOSE: To evaluate the influence of hepatitis B virus (HBV) infection in men of serodiscordant couples on the reproductive outcomes | ||
| 520 | |a MATERIALS AND METHODS: A total of 134 infertile couples were included in this retrospective single-center cohort study. Sixty-six couples had hepatitis B surface antigen (HBsAg)-seropositive men and seronegative partners, while 68 couples were controls with both seronegative men and women. Overall, 134 fresh in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments were performed. As the main outcome measures, on the day of the fresh IVF/ICSI cycle, we assessed seminal parameters Before and after sperm preparation techniques. Two-pronuclear (2PN) fertilization, 1-2-3PN fertilization, cleavage, miscarriage, pregnancy and live birth rates were collected | ||
| 520 | |a RESULTS: No significant differences were found between groups in terms of oocytes retrieved, oocytes injected and embryos obtained (p=0.64, p=0.97, and p=0.40, respectively). The 2PN fertilization rate (FR) was comparable among groups (p=0.51). The 1-2-3PN FR was significantly lower in the HBsAg group than in the control group (66.6% vs. 69.7%, respectively). The clinical pregnancy per cycle, implantation, miscarriage and live birth rate were comparable between the HBsAg group and the control group. The median sperm concentration/ml and total sperm count, measured at baseline and after sperm preparation, was comparable between groups (p>0.05). There was a trend toward significant lower progressive motility (35.0% vs. 55.0%; p<0.05) in the HBsAg group at baseline and after sperm preparation (p<0.05) | ||
| 520 | |a CONCLUSIONS: HBV infected men have the same chance to became father, compared to seronegative patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anti-hepatitis B antigens | |
| 650 | 4 | |a Hepatitis B virus | |
| 650 | 4 | |a In Vitro fertilization | |
| 650 | 4 | |a Infection | |
| 650 | 4 | |a Intracytoplasmic sperm injections | |
| 650 | 4 | |a Male infertility | |
| 700 | 1 | |a Coccia, Maria Elisabetta |e verfasserin |4 aut | |
| 700 | 1 | |a Fucci, Rossella |e verfasserin |4 aut | |
| 700 | 1 | |a Picone, Rita |e verfasserin |4 aut | |
| 700 | 1 | |a Cocci, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Sessa, Maurizio |e verfasserin |4 aut | |
| 700 | 1 | |a Sessa, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Rizzello, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Micelli, Elisabetta |e verfasserin |4 aut | |
| 700 | 1 | |a Trotta, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Badolato, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Campi, Riccardo |e verfasserin |4 aut | |
| 700 | 1 | |a Criscuoli, Luciana |e verfasserin |4 aut | |
| 700 | 1 | |a Serni, Sergio |e verfasserin |4 aut | |
| 700 | 1 | |a Carini, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Natali, Alessandro |e verfasserin |4 aut | |
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