Expert Consensus on a Set of Outcomes to Assess the Effectiveness of Biologic Treatment in Psoriatic Arthritis : The MERECES Study
OBJECTIVE: To reach a consensus on the instruments to be used in clinical practice to evaluate the effectiveness of biological disease-modifying antirheumatic drug (bDMARD) treatment in patients with psoriatic arthritis (PsA) in the short to medium term (3-6 mos), and to establish the minimum health outcomes for treatment continuation.
METHODS: A 2-round Delphi questionnaire was developed based on both the information gathered in the literature review and 4 discussion groups. The suitability and feasibility of the proposed sets of instruments were assessed on a 7-point Likert scale. Consensus was established when at least 75% of healthcare professionals (HCP) reached agreement. To define a minimum health outcome to continue treatment, a combination of 4 disease activity states and 3 health-related quality of life states were defined for 3 hypothetical patient profiles. HCP were given a dichotomous choice (yes/no) to respond to whether they would continue treatment in each case.
RESULTS: The second round was completed by 106 HCP. Consensus was reached on the use of (1) Disease Activity in Psoriatic Arthritis + Psoriatic Arthritis Impact of Disease (PsAID12) or minimal disease activity + PsAID12 + C-reactive protein, in peripheral PsA; and (2) Ankylosing Spondylitis Disease Activity Score + PsAID12, in axial PsA. Health outcomes considered sufficient to continue treatment were stricter for bDMARD-naive patients than for patients who failed several bDMARD.
CONCLUSION: To the best of our knowledge, this is the first multidisciplinary consensus on a set of outcomes for the evaluation of bDMARD effectiveness in PsA, in routine clinical practice.
| Errataetall: |
CommentIn: J Rheumatol. 2020 Nov 1;47(11):1600-1602. - PMID 33139521 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:47 |
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| Enthalten in: |
The Journal of rheumatology - 47(2020), 11 vom: 01. Nov., Seite 1637-1643 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cañete, Juan D [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 25.08.2021 Date Revised 25.08.2021 published: Print-Electronic CommentIn: J Rheumatol. 2020 Nov 1;47(11):1600-1602. - PMID 33139521 Citation Status MEDLINE |
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| doi: |
10.3899/jrheum.191056 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM306035693 |
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| 100 | 1 | |a Cañete, Juan D |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Expert Consensus on a Set of Outcomes to Assess the Effectiveness of Biologic Treatment in Psoriatic Arthritis |b The MERECES Study |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 25.08.2021 | ||
| 500 | |a Date Revised 25.08.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: J Rheumatol. 2020 Nov 1;47(11):1600-1602. - PMID 33139521 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To reach a consensus on the instruments to be used in clinical practice to evaluate the effectiveness of biological disease-modifying antirheumatic drug (bDMARD) treatment in patients with psoriatic arthritis (PsA) in the short to medium term (3-6 mos), and to establish the minimum health outcomes for treatment continuation | ||
| 520 | |a METHODS: A 2-round Delphi questionnaire was developed based on both the information gathered in the literature review and 4 discussion groups. The suitability and feasibility of the proposed sets of instruments were assessed on a 7-point Likert scale. Consensus was established when at least 75% of healthcare professionals (HCP) reached agreement. To define a minimum health outcome to continue treatment, a combination of 4 disease activity states and 3 health-related quality of life states were defined for 3 hypothetical patient profiles. HCP were given a dichotomous choice (yes/no) to respond to whether they would continue treatment in each case | ||
| 520 | |a RESULTS: The second round was completed by 106 HCP. Consensus was reached on the use of (1) Disease Activity in Psoriatic Arthritis + Psoriatic Arthritis Impact of Disease (PsAID12) or minimal disease activity + PsAID12 + C-reactive protein, in peripheral PsA; and (2) Ankylosing Spondylitis Disease Activity Score + PsAID12, in axial PsA. Health outcomes considered sufficient to continue treatment were stricter for bDMARD-naive patients than for patients who failed several bDMARD | ||
| 520 | |a CONCLUSION: To the best of our knowledge, this is the first multidisciplinary consensus on a set of outcomes for the evaluation of bDMARD effectiveness in PsA, in routine clinical practice | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Delphi technique | |
| 650 | 4 | |a antirheumatic agents | |
| 650 | 4 | |a consensus | |
| 650 | 4 | |a patient-reported outcome measures | |
| 650 | 4 | |a psoriatic arthritis | |
| 650 | 4 | |a treatment outcome | |
| 650 | 7 | |a Antirheumatic Agents |2 NLM | |
| 650 | 7 | |a Biological Products |2 NLM | |
| 700 | 1 | |a Nolla, Joan M |e verfasserin |4 aut | |
| 700 | 1 | |a Queiro, Ruben |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez, Miguel J |e verfasserin |4 aut | |
| 700 | 1 | |a Ruiz, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Lizán, Luis |e verfasserin |4 aut | |
| 700 | 0 | |a MERECES Working Group |e verfasserin |4 aut | |
| 700 | 1 | |a Belinchón, Isabel |e investigator |4 oth | |
| 700 | 1 | |a Chamizo, Eugenio |e investigator |4 oth | |
| 700 | 1 | |a Babio, Jesús |e investigator |4 oth | |
| 700 | 1 | |a Almodóvar, Raquel |e investigator |4 oth | |
| 700 | 1 | |a Río, Tamara Del |e investigator |4 oth | |
| 700 | 1 | |a Poveda, José Luis |e investigator |4 oth | |
| 700 | 1 | |a Abad, Ángel |e investigator |4 oth | |
| 700 | 1 | |a Mur, Carlos |e investigator |4 oth | |
| 700 | 1 | |a de la Cueva, Pablo |e investigator |4 oth | |
| 700 | 1 | |a Fernández-Carballido, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Joven, Beatriz |e investigator |4 oth | |
| 700 | 1 | |a Pinto, José A |e investigator |4 oth | |
| 700 | 1 | |a Lozano, Ana |e investigator |4 oth | |
| 700 | 1 | |a León, Leticia |e investigator |4 oth | |
| 700 | 1 | |a Soto, José |e investigator |4 oth | |
| 700 | 1 | |a Galíndez, Eva |e investigator |4 oth | |
| 700 | 1 | |a García-Vivar, Mari L |e investigator |4 oth | |
| 700 | 1 | |a Ruibal, Ana |e investigator |4 oth | |
| 700 | 1 | |a Palmou, Natalia |e investigator |4 oth | |
| 700 | 1 | |a Veroz, Raúl |e investigator |4 oth | |
| 700 | 1 | |a Rubio, Esteban |e investigator |4 oth | |
| 700 | 1 | |a Álvarez-Vega, José L |e investigator |4 oth | |
| 700 | 1 | |a Alonso, Elena |e investigator |4 oth | |
| 700 | 1 | |a Marzo, Jesús |e investigator |4 oth | |
| 700 | 1 | |a Garrido, Laura |e investigator |4 oth | |
| 700 | 1 | |a Fabregas, Lola |e investigator |4 oth | |
| 700 | 1 | |a García-Martos, Álvaro |e investigator |4 oth | |
| 700 | 1 | |a Ortega, María C |e investigator |4 oth | |
| 700 | 1 | |a Díaz, Consuelo |e investigator |4 oth | |
| 700 | 1 | |a Nieto, Juan C |e investigator |4 oth | |
| 700 | 1 | |a Torres, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Pérez-Venegas, Pepe |e investigator |4 oth | |
| 700 | 1 | |a Sanz, Jesús |e investigator |4 oth | |
| 700 | 1 | |a Zarco, Pedro |e investigator |4 oth | |
| 700 | 1 | |a Muñoz, Santiago |e investigator |4 oth | |
| 700 | 1 | |a García-Vicuña, Txaro |e investigator |4 oth | |
| 700 | 1 | |a García-Porrúa, Carlos |e investigator |4 oth | |
| 700 | 1 | |a Meceiras, Francisco J |e investigator |4 oth | |
| 700 | 1 | |a Álvarez-Castro, Carolina |e investigator |4 oth | |
| 700 | 1 | |a Hernández-Beriain, José A |e investigator |4 oth | |
| 700 | 1 | |a González, Beatriz |e investigator |4 oth | |
| 700 | 1 | |a Moreno, Mireia |e investigator |4 oth | |
| 700 | 1 | |a Sellas, Agustí |e investigator |4 oth | |
| 700 | 1 | |a Ramírez, Julio |e investigator |4 oth | |
| 700 | 1 | |a Urruticoechea, Ana |e investigator |4 oth | |
| 700 | 1 | |a Ponce, Andrés |e investigator |4 oth | |
| 700 | 1 | |a Feced, Carlos |e investigator |4 oth | |
| 700 | 1 | |a Martínez-Ferrer, Angels |e investigator |4 oth | |
| 700 | 1 | |a Fernández-Llanio, Nagore |e investigator |4 oth | |
| 700 | 1 | |a Martínez-Cristóbal, Anna |e investigator |4 oth | |
| 700 | 1 | |a Campos, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Conesa, Arantxa |e investigator |4 oth | |
| 700 | 1 | |a Batlle, Enrique |e investigator |4 oth | |
| 700 | 1 | |a Sivera, Francisca |e investigator |4 oth | |
| 700 | 1 | |a Jovaní, Vega |e investigator |4 oth | |
| 700 | 1 | |a Judez, Enrique |e investigator |4 oth | |
| 700 | 1 | |a Moreno, Manuel |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez-Martínez, Fernando |e investigator |4 oth | |
| 700 | 1 | |a Laiz, Ana María |e investigator |4 oth | |
| 700 | 1 | |a Mateo, Lourdes |e investigator |4 oth | |
| 700 | 1 | |a Pujol, Manel |e investigator |4 oth | |
| 700 | 1 | |a Torre, Juan C |e investigator |4 oth | |
| 700 | 1 | |a Coto, Pablo |e investigator |4 oth | |
| 700 | 1 | |a Notario, Jaume |e investigator |4 oth | |
| 700 | 1 | |a García-Font, Mercé |e investigator |4 oth | |
| 700 | 1 | |a Chaves, Antonio J |e investigator |4 oth | |
| 700 | 1 | |a Pujol, Conrad |e investigator |4 oth | |
| 700 | 1 | |a Puig, Lluis |e investigator |4 oth | |
| 700 | 1 | |a Daudén, Esteban |e investigator |4 oth | |
| 700 | 1 | |a Sánchez-Carazo, José L |e investigator |4 oth | |
| 700 | 1 | |a Carretero, Gregorio |e investigator |4 oth | |
| 700 | 1 | |a López-Estebaranz, José L |e investigator |4 oth | |
| 700 | 1 | |a López-Ferrer, Anna |e investigator |4 oth | |
| 700 | 1 | |a Pereyra-Rodriguez, Jose-Juan |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez-Fernández, Lourdes |e investigator |4 oth | |
| 700 | 1 | |a Carrascosa, José M |e investigator |4 oth | |
| 700 | 1 | |a Herranz, Pedro |e investigator |4 oth | |
| 700 | 1 | |a Ruiz-Villaverde, Ricardo |e investigator |4 oth | |
| 700 | 1 | |a Turrión, Ana |e investigator |4 oth | |
| 700 | 1 | |a Cuervo, Andrea M |e investigator |4 oth | |
| 700 | 1 | |a Montilla, Carlos A |e investigator |4 oth | |
| 700 | 1 | |a Delgado, Concepción |e investigator |4 oth | |
| 700 | 1 | |a Palma, Deseada |e investigator |4 oth | |
| 700 | 1 | |a García-Llorente, José F |e investigator |4 oth | |
| 700 | 1 | |a Rosales, José L |e investigator |4 oth | |
| 700 | 1 | |a Senabre, José M |e investigator |4 oth | |
| 700 | 1 | |a Lerma, Juan J |e investigator |4 oth | |
| 700 | 1 | |a Moreno, María J |e investigator |4 oth | |
| 700 | 1 | |a López-Lasanta, María |e investigator |4 oth | |
| 700 | 1 | |a Oliva, María R |e investigator |4 oth | |
| 700 | 1 | |a Navío, María T |e investigator |4 oth | |
| 700 | 1 | |a Tejón, Patricia |e investigator |4 oth | |
| 700 | 1 | |a Castañeda, Santos |e investigator |4 oth | |
| 700 | 1 | |a Alonso-Castro, Sara |e investigator |4 oth | |
| 700 | 1 | |a González-Suárez, Senen |e investigator |4 oth | |
| 700 | 1 | |a Torrente, Vicente |e investigator |4 oth | |
| 700 | 1 | |a García-Portales, Rosa |e investigator |4 oth | |
| 700 | 1 | |a Cancio, Jorge |e investigator |4 oth | |
| 700 | 1 | |a Navarro, Victoria |e investigator |4 oth | |
| 700 | 1 | |a Medina, Julio A |e investigator |4 oth | |
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