Generation of induced pluripotent stem cell line (ZZUi0016-A) from dermal fibroblasts of a normal human
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved..
Dermal fibroblasts obtained from a 43-year-old healthy man were successfully transformed into induced pluripotent stem cells (iPSCs) by employing episomal plasmids expressing OCT3/4, SOX2, KLF4, LIN28, and l-MYC. The iPSCs showed a normal karyotype and exhibited the potential to differentiate into three germ layers in a teratoma assay, which is often used to assess the pluripotency of stem cells. This iPSC line may be subsequently used for drug screens, biological tissue engineering, and cell transplantations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Stem cell research - 43(2020) vom: 15. März, Seite 101717 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gao, Yuan [VerfasserIn] |
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| Anmerkungen: |
Date Completed 21.01.2021 Date Revised 04.12.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.scr.2020.101717 |
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| 520 | |a Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a Dermal fibroblasts obtained from a 43-year-old healthy man were successfully transformed into induced pluripotent stem cells (iPSCs) by employing episomal plasmids expressing OCT3/4, SOX2, KLF4, LIN28, and l-MYC. The iPSCs showed a normal karyotype and exhibited the potential to differentiate into three germ layers in a teratoma assay, which is often used to assess the pluripotency of stem cells. This iPSC line may be subsequently used for drug screens, biological tissue engineering, and cell transplantations | ||
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| 700 | 1 | |a Wang, Zhuoya |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Huifang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yutao |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Han |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Shoutao |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Changhe |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Yuming |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Bo |e verfasserin |4 aut | |
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