Risk of Postoperative Up Staging or Upgrading among Men with Low Risk Familial Prostate Cancer
PURPOSE: We investigated whether men with biopsy verified, low grade cancer and a family history of lethal or advanced prostate cancer are at particularly high risk for harboring undetected high grade disease.
MATERIALS AND METHODS: Upgrading and up staging of prostate cancer are common after prostatectomy. In a nationwide population based cohort we identified 6,854 men with low risk prostate cancer who underwent radical prostatectomy. Among these men 1,739 (25%) had a history of prostate cancer in a first-degree relative and 289 (4%) had a first-degree relative with lethal or advanced prostate cancer.
RESULTS: Compared to men with no familial occurrence of prostate cancer, the odds ratio for the risk of up staging among men with a familial occurrence of high risk or lethal prostate cancer was 1.06 (95% CI 0.76-1.47). The corresponding odds ratio for upgrading was 1.17 (0.91-1.50).
CONCLUSIONS: We found no association between family history of prostate cancer and up staging or upgrading after radical prostatectomy.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:204 |
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| Enthalten in: |
The Journal of urology - 204(2020), 1 vom: 02. Juli, Seite 79-81 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jansson, Fredrik [VerfasserIn] |
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| Links: |
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| Themen: |
EC 3.4.21.77 |
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| Anmerkungen: |
Date Completed 03.08.2020 Date Revised 03.08.2020 published: Print-Electronic CommentIn: J Urol. 2020 Jul;204(1):89-90. - PMID 32329648 Citation Status MEDLINE |
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| doi: |
10.1097/JU.0000000000000793 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM305993038 |
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| 100 | 1 | |a Jansson, Fredrik |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Risk of Postoperative Up Staging or Upgrading among Men with Low Risk Familial Prostate Cancer |
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| 500 | |a Date Completed 03.08.2020 | ||
| 500 | |a Date Revised 03.08.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: J Urol. 2020 Jul;204(1):89-90. - PMID 32329648 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: We investigated whether men with biopsy verified, low grade cancer and a family history of lethal or advanced prostate cancer are at particularly high risk for harboring undetected high grade disease | ||
| 520 | |a MATERIALS AND METHODS: Upgrading and up staging of prostate cancer are common after prostatectomy. In a nationwide population based cohort we identified 6,854 men with low risk prostate cancer who underwent radical prostatectomy. Among these men 1,739 (25%) had a history of prostate cancer in a first-degree relative and 289 (4%) had a first-degree relative with lethal or advanced prostate cancer | ||
| 520 | |a RESULTS: Compared to men with no familial occurrence of prostate cancer, the odds ratio for the risk of up staging among men with a familial occurrence of high risk or lethal prostate cancer was 1.06 (95% CI 0.76-1.47). The corresponding odds ratio for upgrading was 1.17 (0.91-1.50) | ||
| 520 | |a CONCLUSIONS: We found no association between family history of prostate cancer and up staging or upgrading after radical prostatectomy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a neoplasm grading | |
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| 700 | 1 | |a Bratt, Ola |e verfasserin |4 aut | |
| 700 | 1 | |a Akre, Olof |e verfasserin |4 aut | |
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