Probing Anti-Proliferative 24-Homoscalaranes from a Sponge Lendenfeldiasp
In the current study, an NMR spectroscopic pattern-based procedure for probing scalarane derivatives was performed and four new 24-homoscalaranes, lendenfeldaranes A-D (1- 4), along with three known compounds, 12α-acetoxy-22-hydroxy-24-methyl-24-oxoscalar-16-en- 25-al (5), felixin F (6), and 24-methyl-12,24,25-trioxoscalar-16-en-22-oic acid (7) were isolated from the sponge Lendenfeldia sp. The structures of scalaranes 1-7 were elucidated on the basis of spectroscopic analysis. Scalaranes 1-7 were further evaluated for their cytotoxicity toward a series of human cancer cell lines and the results suggested that 5 and 7 dominated in the anti- proliferative activity of the extract. The 18-aldehyde functionality was found to play a key role in their activity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Marine drugs - 18(2020), 2 vom: 24. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Peng, Bo-Rong [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-proliferation |
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| Anmerkungen: |
Date Completed 13.10.2020 Date Revised 13.10.2020 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/md18020076 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM305876295 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a In the current study, an NMR spectroscopic pattern-based procedure for probing scalarane derivatives was performed and four new 24-homoscalaranes, lendenfeldaranes A-D (1- 4), along with three known compounds, 12α-acetoxy-22-hydroxy-24-methyl-24-oxoscalar-16-en- 25-al (5), felixin F (6), and 24-methyl-12,24,25-trioxoscalar-16-en-22-oic acid (7) were isolated from the sponge Lendenfeldia sp. The structures of scalaranes 1-7 were elucidated on the basis of spectroscopic analysis. Scalaranes 1-7 were further evaluated for their cytotoxicity toward a series of human cancer cell lines and the results suggested that 5 and 7 dominated in the anti- proliferative activity of the extract. The 18-aldehyde functionality was found to play a key role in their activity | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Lai, Kuei-Hung |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, You-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Jui-Hsin |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Yusheng M |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yu-Hsin |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Mei-Chin |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Steve Sheng-Fa |e verfasserin |4 aut | |
| 700 | 1 | |a Duh, Chang-Yih |e verfasserin |4 aut | |
| 700 | 1 | |a Sung, Ping-Jyun |e verfasserin |4 aut | |
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