Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood Acute Lymphoblastic Leukemia
Copyright © 2020 Elsevier Inc. All rights reserved..
There are few biomarkers to predict efficacy of glucocorticoid treatment in childhood acute lymphoblastic leukemia (ALL) at diagnosis. Here, we demonstrate reciprocal regulation of 11beta-hydroxysteroid dehydrogenase (11β-HSD), may predict the apoptotic response of ALL to glucocorticoid treatment. Our data may be useful to refine glucocorticoid treatment, to retain benefit while minimizing side effects.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:220 |
|---|---|
| Enthalten in: |
The Journal of pediatrics - 220(2020) vom: 22. Mai, Seite 249-253 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Sai, Shuji [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 24.09.2020 Date Revised 24.09.2020 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.jpeds.2019.12.054 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM305838490 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM305838490 | ||
| 003 | DE-627 | ||
| 005 | 20231225122039.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jpeds.2019.12.054 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1019.xml |
| 035 | |a (DE-627)NLM305838490 | ||
| 035 | |a (NLM)31987650 | ||
| 035 | |a (PII)S0022-3476(19)31733-0 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Sai, Shuji |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood Acute Lymphoblastic Leukemia |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 24.09.2020 | ||
| 500 | |a Date Revised 24.09.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Inc. All rights reserved. | ||
| 520 | |a There are few biomarkers to predict efficacy of glucocorticoid treatment in childhood acute lymphoblastic leukemia (ALL) at diagnosis. Here, we demonstrate reciprocal regulation of 11beta-hydroxysteroid dehydrogenase (11β-HSD), may predict the apoptotic response of ALL to glucocorticoid treatment. Our data may be useful to refine glucocorticoid treatment, to retain benefit while minimizing side effects | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a 11β-HSD | |
| 650 | 4 | |a glucocorticoid resistance | |
| 650 | 4 | |a leukemia | |
| 650 | 7 | |a Glucocorticoids |2 NLM | |
| 650 | 7 | |a Dexamethasone |2 NLM | |
| 650 | 7 | |a 7S5I7G3JQL |2 NLM | |
| 650 | 7 | |a Prednisolone |2 NLM | |
| 650 | 7 | |a 9PHQ9Y1OLM |2 NLM | |
| 650 | 7 | |a 11-beta-Hydroxysteroid Dehydrogenase Type 1 |2 NLM | |
| 650 | 7 | |a EC 1.1.1.146 |2 NLM | |
| 650 | 7 | |a 11-beta-Hydroxysteroid Dehydrogenase Type 2 |2 NLM | |
| 650 | 7 | |a EC 1.1.1.146 |2 NLM | |
| 650 | 7 | |a HSD11B1 protein, human |2 NLM | |
| 650 | 7 | |a EC 1.1.1.146 |2 NLM | |
| 650 | 7 | |a HSD11B2 protein, human |2 NLM | |
| 650 | 7 | |a EC 1.1.1.146 |2 NLM | |
| 700 | 1 | |a Esteves, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Kelly, Val |e verfasserin |4 aut | |
| 700 | 1 | |a Sakaguchi, Kimiyoshi |e verfasserin |4 aut | |
| 700 | 1 | |a McAndrew, Rachel |e verfasserin |4 aut | |
| 700 | 1 | |a Chudleigh, Sandra |e verfasserin |4 aut | |
| 700 | 1 | |a Spence, Alison |e verfasserin |4 aut | |
| 700 | 1 | |a Gibson, Brenda |e verfasserin |4 aut | |
| 700 | 1 | |a Thomas, Angela |e verfasserin |4 aut | |
| 700 | 1 | |a Chapman, Karen E |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Journal of pediatrics |d 1945 |g 220(2020) vom: 22. Mai, Seite 249-253 |w (DE-627)NLM000019003 |x 1097-6833 |7 nnns |
| 773 | 1 | 8 | |g volume:220 |g year:2020 |g day:22 |g month:05 |g pages:249-253 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jpeds.2019.12.054 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 220 |j 2020 |b 22 |c 05 |h 249-253 | ||