Competing risks analysis of the association between perioperative blood transfusion and long-term outcomes after resection of colorectal cancer
Colorectal Disease © 2020 The Association of Coloproctology of Great Britain and Ireland..
AIM: Despite numerous reports over three decades, the association between perioperative blood transfusion and long-term outcomes after resection of colorectal cancer remains controversial. This cohort study used competing risks statistical methods to examine the association between transfusion and recurrence and colorectal cancer-specific death after potentially curative and noncurative resection.
METHOD: A hospital database provided prospectively recorded clinical, operative and follow-up information. All surviving patients were followed for at least 5 years. Data were analysed by multivariable competing risks regression.
RESULTS: From 2575 patients in the period 1995-2010 inclusive, after exclusions, 2334 remained for analysis. Among 1941 who had a potentially curative resection and 393 who had a noncurative resection the transfusion rates were 24.9% and 33.6%, respectively. After potentially curative resection there was no significant bivariate association between transfusion and recurrence (HR 0.93, CI 0.74-1.16, P = 0.499) or between transfusion and colorectal cancer-specific death (HR 1.04, CI 0.82-1.33, P = 0.753). After noncurative resection there was no significant association between transfusion and cancer-specific death (HR 0.93, CI 0.73-1.19, P = 0.560). Multivariable models showed no material effect of potential confounder variables on these results.
CONCLUSION: The competing risks findings in this study showed no significant association between perioperative transfusion and recurrence or colorectal cancer-specific death.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland - 22(2020), 8 vom: 27. Aug., Seite 871-884 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dent, O F [VerfasserIn] |
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| Links: |
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| Themen: |
Blood transfusion |
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| Anmerkungen: |
Date Completed 18.08.2021 Date Revised 18.08.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/codi.14970 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM305585711 |
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| 245 | 1 | 0 | |a Competing risks analysis of the association between perioperative blood transfusion and long-term outcomes after resection of colorectal cancer |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 18.08.2021 | ||
| 500 | |a Date Revised 18.08.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Colorectal Disease © 2020 The Association of Coloproctology of Great Britain and Ireland. | ||
| 520 | |a AIM: Despite numerous reports over three decades, the association between perioperative blood transfusion and long-term outcomes after resection of colorectal cancer remains controversial. This cohort study used competing risks statistical methods to examine the association between transfusion and recurrence and colorectal cancer-specific death after potentially curative and noncurative resection | ||
| 520 | |a METHOD: A hospital database provided prospectively recorded clinical, operative and follow-up information. All surviving patients were followed for at least 5 years. Data were analysed by multivariable competing risks regression | ||
| 520 | |a RESULTS: From 2575 patients in the period 1995-2010 inclusive, after exclusions, 2334 remained for analysis. Among 1941 who had a potentially curative resection and 393 who had a noncurative resection the transfusion rates were 24.9% and 33.6%, respectively. After potentially curative resection there was no significant bivariate association between transfusion and recurrence (HR 0.93, CI 0.74-1.16, P = 0.499) or between transfusion and colorectal cancer-specific death (HR 1.04, CI 0.82-1.33, P = 0.753). After noncurative resection there was no significant association between transfusion and cancer-specific death (HR 0.93, CI 0.73-1.19, P = 0.560). Multivariable models showed no material effect of potential confounder variables on these results | ||
| 520 | |a CONCLUSION: The competing risks findings in this study showed no significant association between perioperative transfusion and recurrence or colorectal cancer-specific death | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a blood transfusion | |
| 650 | 4 | |a colorectal cancer | |
| 650 | 4 | |a long-term outcomes | |
| 650 | 4 | |a resection | |
| 700 | 1 | |a Ripley, J E |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, C |e verfasserin |4 aut | |
| 700 | 1 | |a Rickard, M J F X |e verfasserin |4 aut | |
| 700 | 1 | |a Keshava, A |e verfasserin |4 aut | |
| 700 | 1 | |a Stewart, P |e verfasserin |4 aut | |
| 700 | 1 | |a Chapuis, P H |e verfasserin |4 aut | |
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