Renal detection of Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi in malaria associated acute kidney injury : a retrospective case-control study
OBJECTIVE: Acute kidney injury (AKI) is a frequent presentation in malaria infections. Several cases of AKI that are accompanied by clinical symptoms of malaria infection, such as fever, nausea, respiratory distress, and anemia remain undiagnosed due to challenges in accurate diagnosis using peripheral blood microscopy and rapid diagnostic tests that are currently used in clinical settings. This is particularly true for P. vivax and P. knowlesi infections. As a result, these patients are not able to receive anti-malarial therapy in a timely manner. The objective of the present study was to investigate if patients presenting with AKI harbored any of the five human Plasmodium species (P. falciparum, P. vivax, P. knowlesi, P. malariae, and P. ovale) within their renal tissues.
RESULTS: We found that renal biopsies from malaria associated AKI patients harbor the human malaria parasites P. falciparum, P. vivax and P. knowlesi as mono- and mixed species infections. Presence of microvascular injury in a majority of the malaria associated AKI cases suggested vascular involvement of P. vivax and P. knowlesi. This research note also highlights P. knowlesi as an emerging pathogen in the Indian subcontinent.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
BMC research notes - 13(2020), 1 vom: 20. Jan., Seite 37 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kaur, Charandeep [VerfasserIn] |
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| Links: |
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| Themen: |
Acute kidney injury (AKI) |
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| Anmerkungen: |
Date Completed 08.06.2020 Date Revised 08.06.2020 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s13104-020-4900-1 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM305572725 |
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| 245 | 1 | 0 | |a Renal detection of Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi in malaria associated acute kidney injury |b a retrospective case-control study |
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| 500 | |a Date Revised 08.06.2020 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: Acute kidney injury (AKI) is a frequent presentation in malaria infections. Several cases of AKI that are accompanied by clinical symptoms of malaria infection, such as fever, nausea, respiratory distress, and anemia remain undiagnosed due to challenges in accurate diagnosis using peripheral blood microscopy and rapid diagnostic tests that are currently used in clinical settings. This is particularly true for P. vivax and P. knowlesi infections. As a result, these patients are not able to receive anti-malarial therapy in a timely manner. The objective of the present study was to investigate if patients presenting with AKI harbored any of the five human Plasmodium species (P. falciparum, P. vivax, P. knowlesi, P. malariae, and P. ovale) within their renal tissues | ||
| 520 | |a RESULTS: We found that renal biopsies from malaria associated AKI patients harbor the human malaria parasites P. falciparum, P. vivax and P. knowlesi as mono- and mixed species infections. Presence of microvascular injury in a majority of the malaria associated AKI cases suggested vascular involvement of P. vivax and P. knowlesi. This research note also highlights P. knowlesi as an emerging pathogen in the Indian subcontinent | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute kidney injury (AKI) | |
| 650 | 4 | |a Complicated malaria | |
| 650 | 4 | |a Plasmodium | |
| 650 | 4 | |a Renal tissue | |
| 650 | 4 | |a Severe malaria | |
| 650 | 4 | |a falciparum | |
| 650 | 4 | |a knowlesi | |
| 650 | 4 | |a vivax | |
| 700 | 1 | |a Pramanik, Atreyi |e verfasserin |4 aut | |
| 700 | 1 | |a Kumari, Kalpana |e verfasserin |4 aut | |
| 700 | 1 | |a Mandage, Rajendra |e verfasserin |4 aut | |
| 700 | 1 | |a Dinda, Amit Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Sankar, Jhuma |e verfasserin |4 aut | |
| 700 | 1 | |a Bagga, Arvind |e verfasserin |4 aut | |
| 700 | 1 | |a Agarwal, Sanjay Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Sinha, Aditi |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, Geetika |e verfasserin |4 aut | |
| 700 | 1 | |a Acharya, Pragyan |e verfasserin |4 aut | |
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