Clinical utility of fractional exhaled nitric oxide in severe asthma management
Copyright ©ERS 2020..
Asthma is a chronic inflammatory disease of the airways, affecting over 350 million people worldwide and placing a significant burden on healthcare providers and wider society. Approximately 5-10% of asthma patients are diagnosed with severe asthma and typically are associated with increased risk of hospitalisation from exacerbations, increased morbidity, mortality and higher asthma-associated healthcare costs. Nitric oxide (NO) is an important regulator of immune responses and is a product of inflammation in the airways that is over-produced in asthma. Fractional exhaled NO (F eNO) is predominantly used as a predictor of response to inhaled corticosteroids (ICSs), to monitor adherence and as a diagnostic tool in ICS-naïve patients. In the UK, the National Institute for Health and Care Excellence (NICE) guidelines recommend the use of F eNO for the initial diagnosis of patients with suspected asthma. In the USA, American Thoracic Society (ATS) guidelines recommend F eNO as part of the initial diagnosis of asthma and for monitoring of airway inflammation. F eNO has also been shown to be a predictive factor for asthma exacerbations, with higher levels being associated with a greater number of exacerbations. In addition, higher levels of F eNO have been shown to be associated with a decline in lung function. F eNO testing is a cost-effective procedure and has been shown to improve patient management when combined with standard assessment methods. Recent evidence suggests that F eNO may also be useful as a surrogate biomarker for the assessment and management of severe asthma and to predict responsiveness to some biological therapies.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:55 |
---|---|
Enthalten in: |
The European respiratory journal - 55(2020), 3 vom: 26. März |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Menzies-Gow, Andrew [VerfasserIn] |
---|
Links: |
---|
Themen: |
31C4KY9ESH |
---|
Anmerkungen: |
Date Completed 21.06.2021 Date Revised 21.06.2021 published: Electronic-Print Citation Status MEDLINE |
---|
doi: |
10.1183/13993003.01633-2019 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM305474057 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM305474057 | ||
003 | DE-627 | ||
005 | 20231225121247.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2020 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1183/13993003.01633-2019 |2 doi | |
028 | 5 | 2 | |a pubmed24n1018.xml |
035 | |a (DE-627)NLM305474057 | ||
035 | |a (NLM)31949116 | ||
035 | |a (PII)1901633 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Menzies-Gow, Andrew |e verfasserin |4 aut | |
245 | 1 | 0 | |a Clinical utility of fractional exhaled nitric oxide in severe asthma management |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 21.06.2021 | ||
500 | |a Date Revised 21.06.2021 | ||
500 | |a published: Electronic-Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright ©ERS 2020. | ||
520 | |a Asthma is a chronic inflammatory disease of the airways, affecting over 350 million people worldwide and placing a significant burden on healthcare providers and wider society. Approximately 5-10% of asthma patients are diagnosed with severe asthma and typically are associated with increased risk of hospitalisation from exacerbations, increased morbidity, mortality and higher asthma-associated healthcare costs. Nitric oxide (NO) is an important regulator of immune responses and is a product of inflammation in the airways that is over-produced in asthma. Fractional exhaled NO (F eNO) is predominantly used as a predictor of response to inhaled corticosteroids (ICSs), to monitor adherence and as a diagnostic tool in ICS-naïve patients. In the UK, the National Institute for Health and Care Excellence (NICE) guidelines recommend the use of F eNO for the initial diagnosis of patients with suspected asthma. In the USA, American Thoracic Society (ATS) guidelines recommend F eNO as part of the initial diagnosis of asthma and for monitoring of airway inflammation. F eNO has also been shown to be a predictive factor for asthma exacerbations, with higher levels being associated with a greater number of exacerbations. In addition, higher levels of F eNO have been shown to be associated with a decline in lung function. F eNO testing is a cost-effective procedure and has been shown to improve patient management when combined with standard assessment methods. Recent evidence suggests that F eNO may also be useful as a surrogate biomarker for the assessment and management of severe asthma and to predict responsiveness to some biological therapies | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Review | |
650 | 7 | |a Adrenal Cortex Hormones |2 NLM | |
650 | 7 | |a Biomarkers |2 NLM | |
650 | 7 | |a Nitric Oxide |2 NLM | |
650 | 7 | |a 31C4KY9ESH |2 NLM | |
700 | 1 | |a Mansur, Adel H |e verfasserin |4 aut | |
700 | 1 | |a Brightling, Christopher E |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t The European respiratory journal |d 1989 |g 55(2020), 3 vom: 26. März |w (DE-627)NLM012664782 |x 0903-1936 |7 nnns |
773 | 1 | 8 | |g volume:55 |g year:2020 |g number:3 |g day:26 |g month:03 |
856 | 4 | 0 | |u http://dx.doi.org/10.1183/13993003.01633-2019 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 55 |j 2020 |e 3 |b 26 |c 03 |