Multidisciplinary meetings determining the imputability of xenobiotics in causes of death : What contribution to pharmacovigilance data?
Copyright © 2019 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved..
PURPOSE: In case of xenobiotics induced toxic deaths analyzed at the university hospital of Rennes, a multidisplinary team of forensic analysts, toxicologists, anatomopathologists and pharmacologists assess xenobiotics' contribution to the death.
METHODS: A death contribution score (SCRIM) is collectively established during meetings for each death involving xenobiotic drugs. Graded between 1 and 6, lower was this score, more certain was the imputability. Among deaths with the highest imputability, drug poisonings were isolated.
RESULTS: Analysis of 266 deaths presented at meetings over the period 2010-2017 highlight a lot of drug medicine poisonings (60%). The main classes implicated are: opioid substitution treatments (24%) followed by anxiolytics (23%), antidepressants (16%), legal opioids (16%) and antipsychotics (14%). Analysis of these cases by Rennes regional pharmacovigilance center permits to obtain a qualitative signal by establishing a local overview of the main risk classes but also to highlight a specific signal, in particular for oxycodone and antihistamines.
CONCLUSIONS: This multidisciplinary approach shows that a majority of toxic deaths are attributed to drugs. Mortality attributed to oxycodone and antihistamines is a specific signal that should be closely monitored.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:75 |
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| Enthalten in: |
Therapie - 75(2020), 5 vom: 10. Sept., Seite 481-490 |
| Sprache: |
Französisch |
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| Weiterer Titel: |
Réunions pluridisciplinaires déterminant l’imputabilité des xénobiotiques dans les causes de la mort : quel apport aux données de pharmacovigilance ? |
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| Beteiligte Personen: |
Lalanne, Sébastien [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 17.09.2021 Date Revised 17.09.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.therap.2019.10.005 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM305253581 |
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| 245 | 1 | 0 | |a Multidisciplinary meetings determining the imputability of xenobiotics in causes of death |b What contribution to pharmacovigilance data? |
| 246 | 3 | 3 | |a Réunions pluridisciplinaires déterminant l’imputabilité des xénobiotiques dans les causes de la mort : quel apport aux données de pharmacovigilance ? |
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| 500 | |a Date Revised 17.09.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved. | ||
| 520 | |a PURPOSE: In case of xenobiotics induced toxic deaths analyzed at the university hospital of Rennes, a multidisplinary team of forensic analysts, toxicologists, anatomopathologists and pharmacologists assess xenobiotics' contribution to the death | ||
| 520 | |a METHODS: A death contribution score (SCRIM) is collectively established during meetings for each death involving xenobiotic drugs. Graded between 1 and 6, lower was this score, more certain was the imputability. Among deaths with the highest imputability, drug poisonings were isolated | ||
| 520 | |a RESULTS: Analysis of 266 deaths presented at meetings over the period 2010-2017 highlight a lot of drug medicine poisonings (60%). The main classes implicated are: opioid substitution treatments (24%) followed by anxiolytics (23%), antidepressants (16%), legal opioids (16%) and antipsychotics (14%). Analysis of these cases by Rennes regional pharmacovigilance center permits to obtain a qualitative signal by establishing a local overview of the main risk classes but also to highlight a specific signal, in particular for oxycodone and antihistamines | ||
| 520 | |a CONCLUSIONS: This multidisciplinary approach shows that a majority of toxic deaths are attributed to drugs. Mortality attributed to oxycodone and antihistamines is a specific signal that should be closely monitored | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Analyse médicolégale | |
| 650 | 4 | |a Antihistaminiques | |
| 650 | 4 | |a Cause of death | |
| 650 | 4 | |a Causes de la mort | |
| 650 | 4 | |a Forensic toxicology | |
| 650 | 4 | |a Histamine antagonists | |
| 650 | 4 | |a Opiacés | |
| 650 | 4 | |a Opiates | |
| 650 | 4 | |a Pharmacovigilance | |
| 650 | 4 | |a Xenobiotics | |
| 650 | 4 | |a Xénobiotiques | |
| 650 | 7 | |a Analgesics, Opioid |2 NLM | |
| 650 | 7 | |a Xenobiotics |2 NLM | |
| 650 | 7 | |a Oxycodone |2 NLM | |
| 650 | 7 | |a CD35PMG570 |2 NLM | |
| 700 | 1 | |a Caradec, Quentin |e verfasserin |4 aut | |
| 700 | 1 | |a Baert, Alain |e verfasserin |4 aut | |
| 700 | 1 | |a Bouvet, Renaud |e verfasserin |4 aut | |
| 700 | 1 | |a Morel, Isabelle |e verfasserin |4 aut | |
| 700 | 1 | |a Polard, Elisabeth |e verfasserin |4 aut | |
| 700 | 1 | |a Gicquel, Thomas |e verfasserin |4 aut | |
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