Effect of margin status and pathological grade in treatment of sinonasal mucoepidermoid carcinoma
© 2020 The American Laryngological, Rhinological and Otological Society, Inc..
OBJECTIVES: The purpose of this study was to investigate the association of demographic factors, grade, margin status, and treatment modalities for overall survival in patients with sinonasal mucoepidermoid carcinoma (SNMEC).
STUDY DESIGN: Retrospective database review.
METHODS: The National Cancer Database was queried for patients of all ages with SNMEC between 2004 and 2015. Univariate Kaplan-Meier and multivariate Cox regression analyses were performed to evaluate the association of suspected prognostic factors with overall survival. Subgroup analysis by margin status and grade was performed.
RESULTS: A total of 239 patients with SNMEC were included in the analysis. The 5-year overall survival was 63.6%. Prognostic factors associated with decreased survival include age over 70 years (P = .027), sphenoid primary site (P = .002), and advanced-stage malignancy (P = .024). Improved survival was associated with surgery achieving negative margins (P = .001). Adjuvant radiation was associated with improved survival (hazard ratio [HR] = 0.25, P = .015) in the negative-margin group but was not found to be a statistically significant factor in the positive-margin group (HR = 0.66, P = .509).
CONCLUSIONS: This investigation is the largest to date to analyze the association of treatment modalities with overall survival in SNMEC and subgroup analysis by histopathologic grade and surgical margin status of treatment outcomes. Surgery remains the mainstay of treatment in patients with SNMEC. However, administration of radiation may confer survival benefit to patients with negative margins.
LEVEL OF EVIDENCE: 4 Laryngoscope, 2020.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:130 |
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| Enthalten in: |
The Laryngoscope - 130(2020), 12 vom: 01. Dez., Seite E750-E757 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Auger, Samuel R [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 11.01.2021 Date Revised 11.01.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/lary.28499 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM305128639 |
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| 245 | 1 | 0 | |a Effect of margin status and pathological grade in treatment of sinonasal mucoepidermoid carcinoma |
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| 500 | |a Date Revised 11.01.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 The American Laryngological, Rhinological and Otological Society, Inc. | ||
| 520 | |a OBJECTIVES: The purpose of this study was to investigate the association of demographic factors, grade, margin status, and treatment modalities for overall survival in patients with sinonasal mucoepidermoid carcinoma (SNMEC) | ||
| 520 | |a STUDY DESIGN: Retrospective database review | ||
| 520 | |a METHODS: The National Cancer Database was queried for patients of all ages with SNMEC between 2004 and 2015. Univariate Kaplan-Meier and multivariate Cox regression analyses were performed to evaluate the association of suspected prognostic factors with overall survival. Subgroup analysis by margin status and grade was performed | ||
| 520 | |a RESULTS: A total of 239 patients with SNMEC were included in the analysis. The 5-year overall survival was 63.6%. Prognostic factors associated with decreased survival include age over 70 years (P = .027), sphenoid primary site (P = .002), and advanced-stage malignancy (P = .024). Improved survival was associated with surgery achieving negative margins (P = .001). Adjuvant radiation was associated with improved survival (hazard ratio [HR] = 0.25, P = .015) in the negative-margin group but was not found to be a statistically significant factor in the positive-margin group (HR = 0.66, P = .509) | ||
| 520 | |a CONCLUSIONS: This investigation is the largest to date to analyze the association of treatment modalities with overall survival in SNMEC and subgroup analysis by histopathologic grade and surgical margin status of treatment outcomes. Surgery remains the mainstay of treatment in patients with SNMEC. However, administration of radiation may confer survival benefit to patients with negative margins | ||
| 520 | |a LEVEL OF EVIDENCE: 4 Laryngoscope, 2020 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Mucoepidermoid carcinoma, sinonasal, cancer, malignancy, National Cancer Database, overall survival, margins, grade, outcomes | |
| 700 | 1 | |a Patel, Tirth |e verfasserin |4 aut | |
| 700 | 1 | |a Ganti, Ashwin |e verfasserin |4 aut | |
| 700 | 1 | |a Raman, Anish |e verfasserin |4 aut | |
| 700 | 1 | |a Shay, Aryan |e verfasserin |4 aut | |
| 700 | 1 | |a Kuhar, Hannah N |e verfasserin |4 aut | |
| 700 | 1 | |a Kuan, Edward C |e verfasserin |4 aut | |
| 700 | 1 | |a Papagiannopoulos, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Batra, Pete S |e verfasserin |4 aut | |
| 700 | 1 | |a Tajudeen, Bobby A |e verfasserin |4 aut | |
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