Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.
| Errataetall: |
CommentIn: Nat Neurosci. 2020 Feb;23(2):153-154. - PMID 31953526 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Nature neuroscience - 23(2020), 2 vom: 06. Feb., Seite 172-175 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Erlendsson, Simon [VerfasserIn] |
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| Links: |
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| Themen: |
A protein, Drosophila |
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| Anmerkungen: |
Date Completed 13.04.2020 Date Revised 01.04.2023 published: Print-Electronic CommentIn: Nat Neurosci. 2020 Feb;23(2):153-154. - PMID 31953526 Citation Status MEDLINE |
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| doi: |
10.1038/s41593-019-0569-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM305069462 |
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| 245 | 1 | 0 | |a Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Nat Neurosci. 2020 Feb;23(2):153-154. - PMID 31953526 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Shepherd, Jason D |e verfasserin |4 aut | |
| 700 | 1 | |a Briggs, John A G |e verfasserin |4 aut | |
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