Neuroprotective Effect of ent-Kaur-15-en-17-al-18-oic Acid on Amyloid Beta Peptide-Induced Oxidative Apoptosis in Alzheimer's Disease
ent-Kaur-15-en-17-al-18-oic acid, extracted from the Chinese well known folk herb Leontopodium longifolium, performed a significantly neuroprotective effect on amyloid beta peptide 25-35 (Aβ25-35)-induced SH-SY5Y cells neurotoxicity in Alzheimer's disease. The results demonstrated that this compound maintained oxidative stress balance, reduced levels of reactive oxygen species (ROS), malondialdehyde (MDA), and improved contents of glutathione (GSH) and superoxide dismutase (SOD) without obvious cytotoxicity. This compound also obviously relieved oxidative stress-induced apoptosis associated with p53 and nuclear factor κB (NF-κB) pathways accompanied by upregulating B-cell lymphoma-2 (bcl-2) and downregulating p53, nuclear factor κB (NF-κB), Bax, Cleaved-caspase 3, and Cytochrome C protein expressions further. Briefly, ent-kaur-15-en-17-al-18-oic acid protected cells from oxidative apoptosis associated with p53 and NF-κB pathways.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Molecules (Basel, Switzerland) - 25(2019), 1 vom: 29. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Caiyun [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 03.06.2020 Date Revised 03.06.2020 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/molecules25010142 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM305053124 |
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| 100 | 1 | |a Zhang, Caiyun |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Neuroprotective Effect of ent-Kaur-15-en-17-al-18-oic Acid on Amyloid Beta Peptide-Induced Oxidative Apoptosis in Alzheimer's Disease |
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| 500 | |a Date Revised 03.06.2020 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a ent-Kaur-15-en-17-al-18-oic acid, extracted from the Chinese well known folk herb Leontopodium longifolium, performed a significantly neuroprotective effect on amyloid beta peptide 25-35 (Aβ25-35)-induced SH-SY5Y cells neurotoxicity in Alzheimer's disease. The results demonstrated that this compound maintained oxidative stress balance, reduced levels of reactive oxygen species (ROS), malondialdehyde (MDA), and improved contents of glutathione (GSH) and superoxide dismutase (SOD) without obvious cytotoxicity. This compound also obviously relieved oxidative stress-induced apoptosis associated with p53 and nuclear factor κB (NF-κB) pathways accompanied by upregulating B-cell lymphoma-2 (bcl-2) and downregulating p53, nuclear factor κB (NF-κB), Bax, Cleaved-caspase 3, and Cytochrome C protein expressions further. Briefly, ent-kaur-15-en-17-al-18-oic acid protected cells from oxidative apoptosis associated with p53 and NF-κB pathways | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Alzheimer’s disease | |
| 650 | 4 | |a Aβ25-35 | |
| 650 | 4 | |a NF-κB | |
| 650 | 4 | |a SH-SY5Y | |
| 650 | 4 | |a apoptosis | |
| 650 | 4 | |a oxidative stress | |
| 650 | 4 | |a p53 | |
| 650 | 7 | |a Amyloid beta-Peptides |2 NLM | |
| 650 | 7 | |a Drugs, Chinese Herbal |2 NLM | |
| 650 | 7 | |a NF-kappa B |2 NLM | |
| 650 | 7 | |a Neuroprotective Agents |2 NLM | |
| 650 | 7 | |a Reactive Oxygen Species |2 NLM | |
| 650 | 7 | |a Tumor Suppressor Protein p53 |2 NLM | |
| 650 | 7 | |a Superoxide Dismutase |2 NLM | |
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| 650 | 7 | |a Glutathione |2 NLM | |
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| 700 | 1 | |a Zhao, Xingming |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Shiqi |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Fangyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Jiahui |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Zhuo |e verfasserin |4 aut | |
| 700 | 1 | |a Jia, Fujuan |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Weidong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Qian |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xia |e verfasserin |4 aut | |
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