MRI and clinical features of acute fungal discitis/osteomyelitis
OBJECTIVES: To compare imaging and clinical features of fungal and Staphylococcus aureus discitis-osteomyelitis (DO) for patients presenting for CT-guided biopsies.
METHODS: Our study was IRB-approved and HIPAA-compliant. A group of 11 fungal DO (FG) with MRI within 7 days of the biopsy and a control group (CG) of 19 Staphylococcus aureus DO were evaluated. Imaging findings (focal vs diffuse paravertebral soft tissue abnormality, partial vs complete involvement of the disc/endplate), biopsy location, pathology, duration of back pain, immune status, history of intravenous drug, history of prior infection, current antibiotic treatment, and history of invasive intervention. Differences were assessed using the Fisher exact test and Kruskal-Wallis test. Naïve Bayes predictive modeling was performed.
RESULTS: The most common fungal organisms were Candida species (9/11, 82%). The FG was more likely to have focal soft tissue abnormality (p = 0.040) and partial disc/endplate involvement (p = 0.053). The clinical predictors for fungal DO, in order of importance, back pain for 10 or more weeks, current antibiotic use for 1 week or more, and current intravenous drug use. History of invasive instrumentation within 1 year was more predictive of Staphylococcus aureus DO.
CONCLUSION: MRI features (focal partial soft tissue abnormality and partial involvement of the disc/endplate) in combination with clinical features may help to predict fungal species as a causative organism for DO.
KEY POINTS: • MRI features of discitis-osteomyelitis (focal partial soft tissue abnormality and partial involvement of the disc/endplate) in combination with clinical features may help to predict fungal species as a causative organism for DO.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
|---|---|
| Enthalten in: |
European radiology - 30(2020), 4 vom: 03. Apr., Seite 2253-2260 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Simeone, F Joseph [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Bacterial Agents |
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| Anmerkungen: |
Date Completed 14.10.2020 Date Revised 18.04.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00330-019-06603-z |
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| funding: |
|
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM305002791 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
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| 100 | 1 | |a Simeone, F Joseph |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a MRI and clinical features of acute fungal discitis/osteomyelitis |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 14.10.2020 | ||
| 500 | |a Date Revised 18.04.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: To compare imaging and clinical features of fungal and Staphylococcus aureus discitis-osteomyelitis (DO) for patients presenting for CT-guided biopsies | ||
| 520 | |a METHODS: Our study was IRB-approved and HIPAA-compliant. A group of 11 fungal DO (FG) with MRI within 7 days of the biopsy and a control group (CG) of 19 Staphylococcus aureus DO were evaluated. Imaging findings (focal vs diffuse paravertebral soft tissue abnormality, partial vs complete involvement of the disc/endplate), biopsy location, pathology, duration of back pain, immune status, history of intravenous drug, history of prior infection, current antibiotic treatment, and history of invasive intervention. Differences were assessed using the Fisher exact test and Kruskal-Wallis test. Naïve Bayes predictive modeling was performed | ||
| 520 | |a RESULTS: The most common fungal organisms were Candida species (9/11, 82%). The FG was more likely to have focal soft tissue abnormality (p = 0.040) and partial disc/endplate involvement (p = 0.053). The clinical predictors for fungal DO, in order of importance, back pain for 10 or more weeks, current antibiotic use for 1 week or more, and current intravenous drug use. History of invasive instrumentation within 1 year was more predictive of Staphylococcus aureus DO | ||
| 520 | |a CONCLUSION: MRI features (focal partial soft tissue abnormality and partial involvement of the disc/endplate) in combination with clinical features may help to predict fungal species as a causative organism for DO | ||
| 520 | |a KEY POINTS: • MRI features of discitis-osteomyelitis (focal partial soft tissue abnormality and partial involvement of the disc/endplate) in combination with clinical features may help to predict fungal species as a causative organism for DO | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bacteria | |
| 650 | 4 | |a Biopsy | |
| 650 | 4 | |a Discitis | |
| 650 | 4 | |a Fungi | |
| 650 | 4 | |a Magnetic resonance imaging | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 700 | 1 | |a Husseini, Jad S |e verfasserin |4 aut | |
| 700 | 1 | |a Yeh, Kaitlyn J |e verfasserin |4 aut | |
| 700 | 1 | |a Lozano-Calderon, Santiago |e verfasserin |4 aut | |
| 700 | 1 | |a Nelson, Sandra B |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Connie Y |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:30 |g year:2020 |g number:4 |g day:03 |g month:04 |g pages:2253-2260 |
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