Propofol versus Fentanyl for Sedation in Pediatric Bronchoscopy : A Randomized Controlled Trial
OBJECTIVE: To compare propofol and fentanyl to induce conscious sedation in children undergoing flexible bronchoscopy.
STUDY DESIGN: Randomized controlled trial.
SETTING: Pediatric Pulmonology division at a tertiary care center in Delhi, India.
PARTICIPANTS: Children aged 3-15 years who underwent flexible bronchoscopy.
INTERVENTION: Children received either intravenous propofol 1 mg/kg administered as a slow bolus over 1 minute followed by 2 mg/kg/hour infusion, or intravenous Fentanyl 2 µg/kg administered as a slow bolus over one minute.
OUTCOMES: Primary outcome was time to achieve conscious sedation (Ramsay score 3). Secondary outcomes were need for adjuvant midazolam, physician satisfaction, level of cough, recovery features, and side-effects in the groups.
RESULTS: 53 children (propofol 27, fentanyl 26) were enrolled in the study. The mean (SD) time taken to achieve Ramsay score 03 was lower in propofol than fentanyl [15.7 (4.4) s vs 206 (55) s, P<0.001]. Propofol arm had significantly higher physician satisfaction, less requirement of adjuvant midazolam, less coughing and faster regain of full consciousness. There was no difference in drug side-effects between the groups.
CONCLUSIONS: Propofol has a shorter sedation induction time, less coughing during procedure, less recovery time, and better physician satisfaction compared to fentanyl for flexible bronchoscopy in children.
| Errataetall: |
CommentIn: Indian Pediatr. 2020 May 15;57(5):483-484. - PMID 32444528 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:56 |
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| Enthalten in: |
Indian pediatrics - 56(2019), 12 vom: 15. Dez., Seite 1011-1016 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gunathilaka, P K G [VerfasserIn] |
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| Themen: |
Fentanyl |
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| Anmerkungen: |
Date Completed 25.05.2020 Date Revised 25.05.2020 published: Print CommentIn: Indian Pediatr. 2020 May 15;57(5):483-484. - PMID 32444528 Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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NLM304844322 |
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| 500 | |a CommentIn: Indian Pediatr. 2020 May 15;57(5):483-484. - PMID 32444528 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To compare propofol and fentanyl to induce conscious sedation in children undergoing flexible bronchoscopy | ||
| 520 | |a STUDY DESIGN: Randomized controlled trial | ||
| 520 | |a SETTING: Pediatric Pulmonology division at a tertiary care center in Delhi, India | ||
| 520 | |a PARTICIPANTS: Children aged 3-15 years who underwent flexible bronchoscopy | ||
| 520 | |a INTERVENTION: Children received either intravenous propofol 1 mg/kg administered as a slow bolus over 1 minute followed by 2 mg/kg/hour infusion, or intravenous Fentanyl 2 µg/kg administered as a slow bolus over one minute | ||
| 520 | |a OUTCOMES: Primary outcome was time to achieve conscious sedation (Ramsay score 3). Secondary outcomes were need for adjuvant midazolam, physician satisfaction, level of cough, recovery features, and side-effects in the groups | ||
| 520 | |a RESULTS: 53 children (propofol 27, fentanyl 26) were enrolled in the study. The mean (SD) time taken to achieve Ramsay score 03 was lower in propofol than fentanyl [15.7 (4.4) s vs 206 (55) s, P<0.001]. Propofol arm had significantly higher physician satisfaction, less requirement of adjuvant midazolam, less coughing and faster regain of full consciousness. There was no difference in drug side-effects between the groups | ||
| 520 | |a CONCLUSIONS: Propofol has a shorter sedation induction time, less coughing during procedure, less recovery time, and better physician satisfaction compared to fentanyl for flexible bronchoscopy in children | ||
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| 700 | 1 | |a Kabra, S K |e verfasserin |4 aut | |
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