Incidence, Risk Factors, Outcomes, and Risk Score Model of Acute Pancreatitis after Allogeneic Hematopoietic Stem Cell Transplantation

Copyright © 2019. Published by Elsevier Inc..

Acute pancreatitis (AP) has been recognized as an uncommon yet potentially lethal complication after hematopoietic stem cell transplant (HSCT). This retrospective, nested, case-control study reviewed data from 5284 consecutive patients who underwent allogeneic (allo)-HSCT between 2009 and 2018 at a single center, identifying 40 patients (0.76%) with AP after allo-HSCT. The diagnosis and severity of AP were established and classified according to existing criteria. Younger age (P = .008), grades II to IV acute graft-versus-host disease (P = .010), a history of donor lymphocyte infusion (P = .033), and pre-existing gallstones (P = .003) were independent risk factors of AP after allo-HSCT. Post-transplant AP had a trend to negatively influence overall survival (OS) and nonrelapse mortality (NRM) (P = .063) for allo-HSCT recipients, but no significant difference was found. Patients with moderately severe and severe AP had significantly lower OS (P = .002) and higher NRM (P = .000) than other patients. Based on these findings, a risk score model was also established to predict the occurrence of AP. Our risk score model performed well in terms of discrimination when applied to derivation samples. Patients were classified into a low-risk group (0 to 1 point), a medium-risk group (2 to 3 points), and a high-risk group (4 points or more). Significant difference was observed in AP incidence among the 3 groups. The predictive tool explored by our study might contribute to target high-risk patients and guide personalized AP prevention in allo-HSCT recipients.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:26

Enthalten in:

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 26(2020), 6 vom: 19. Juni, Seite 1171-1178

Sprache:

Englisch

Beteiligte Personen:

Wang, Xing-Lin [VerfasserIn]
Han, Wei [VerfasserIn]
Zhao, Peng [VerfasserIn]
Liu, Xiao [VerfasserIn]
Wang, Jing-Zhi [VerfasserIn]
Wang, Feng-Rong [VerfasserIn]
Yan, Chen-Hua [VerfasserIn]
Zhang, Yuan-Yuan [VerfasserIn]
Mo, Xiao-Dong [VerfasserIn]
Wang, Yu [VerfasserIn]
Fu, Hai-Xia [VerfasserIn]
Chen, Yu-Hong [VerfasserIn]
Chang, Ying-Jun [VerfasserIn]
Xu, Lan-Ping [VerfasserIn]
Liu, Kai-Yan [VerfasserIn]
Huang, Xiao-Jun [VerfasserIn]
Zhang, Xiao-Hui [VerfasserIn]

Links:

Volltext

Themen:

Acute pancreatitis
Allogeneic hematopoietic stem cell transplantation
Journal Article
Research Support, Non-U.S. Gov't
Risk prediction

Anmerkungen:

Date Completed 23.06.2021

Date Revised 23.06.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.bbmt.2019.12.721

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM304743828