Children Monosensitized to Can f 5 Show Different Reactions to Male and Female Dog Allergen Extract Provocation : A Randomized Controlled Trial
Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved..
BACKGROUND: Dog dander consists of several allergenic molecules including Can f 5, which is a protein expressed in the prostate of male dogs.
OBJECTIVE: To investigate whether children monosensitized to Can f 5 show different reactions to provocation tests with male versus female dog dander in a double-blind randomized clinical trial.
METHODS: Twenty-two children (15-18 years) with a history of dog sensitization were enrolled from the COpenhagen Prospective Studies on Asthma in Childhood2000 mother-child cohort. Skin prick test, specific IgE levels to dog dander (e5), and dog components Can f 1, 2, 3, and 5 were first assessed. We subsequently performed skin prick test and conjunctival allergen provocation test using dog dander collected separately from male and female dogs.
RESULTS: Seven of the 22 children were monosensitized to Can f 5. Eight were sensitized to a mix of the dog components, and 7 were no longer sensitized to dog. Of the children monosensitized to Can f 5, all had a positive skin prick test result to male dog extract and 1 of 7 was also positive to female dog extract (P = .01). Furthermore, 5 of 7 had a positive conjunctival allergen provocation test result to male dog extract and 1 of 7 also reacted to the female dog extract (P = .03). There was no difference between reactions to male and female dog extract provocation in children sensitized to a mix of the dog components.
CONCLUSIONS: Children monosensitized to Can f 5 show different reactions to male and female dog extract provocation using both skin prick test and conjunctival allergen provocation test, suggesting tolerance to female dogs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
The journal of allergy and clinical immunology. In practice - 8(2020), 5 vom: 01. Mai, Seite 1592-1597.e2 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Schoos, Ann-Marie Malby [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 14.05.2021 Date Revised 14.05.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jaip.2019.12.012 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM30464384X |
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| 100 | 1 | |a Schoos, Ann-Marie Malby |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Children Monosensitized to Can f 5 Show Different Reactions to Male and Female Dog Allergen Extract Provocation |b A Randomized Controlled Trial |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 14.05.2021 | ||
| 500 | |a Date Revised 14.05.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Dog dander consists of several allergenic molecules including Can f 5, which is a protein expressed in the prostate of male dogs | ||
| 520 | |a OBJECTIVE: To investigate whether children monosensitized to Can f 5 show different reactions to provocation tests with male versus female dog dander in a double-blind randomized clinical trial | ||
| 520 | |a METHODS: Twenty-two children (15-18 years) with a history of dog sensitization were enrolled from the COpenhagen Prospective Studies on Asthma in Childhood2000 mother-child cohort. Skin prick test, specific IgE levels to dog dander (e5), and dog components Can f 1, 2, 3, and 5 were first assessed. We subsequently performed skin prick test and conjunctival allergen provocation test using dog dander collected separately from male and female dogs | ||
| 520 | |a RESULTS: Seven of the 22 children were monosensitized to Can f 5. Eight were sensitized to a mix of the dog components, and 7 were no longer sensitized to dog. Of the children monosensitized to Can f 5, all had a positive skin prick test result to male dog extract and 1 of 7 was also positive to female dog extract (P = .01). Furthermore, 5 of 7 had a positive conjunctival allergen provocation test result to male dog extract and 1 of 7 also reacted to the female dog extract (P = .03). There was no difference between reactions to male and female dog extract provocation in children sensitized to a mix of the dog components | ||
| 520 | |a CONCLUSIONS: Children monosensitized to Can f 5 show different reactions to male and female dog extract provocation using both skin prick test and conjunctival allergen provocation test, suggesting tolerance to female dogs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Allergy | |
| 650 | 4 | |a Can f 5 | |
| 650 | 4 | |a Children | |
| 650 | 4 | |a Conjunctival allergen provocation | |
| 650 | 4 | |a Dog allergy | |
| 650 | 4 | |a Female dog | |
| 650 | 4 | |a Male dog | |
| 650 | 4 | |a Monosensitization | |
| 650 | 7 | |a Allergens |2 NLM | |
| 650 | 7 | |a Plant Extracts |2 NLM | |
| 700 | 1 | |a Chawes, Bo Lund |e verfasserin |4 aut | |
| 700 | 1 | |a Bloch, Joakim |e verfasserin |4 aut | |
| 700 | 1 | |a Hansen, Britta |e verfasserin |4 aut | |
| 700 | 1 | |a Stokholm, Jakob |e verfasserin |4 aut | |
| 700 | 1 | |a Bønnelykke, Klaus |e verfasserin |4 aut | |
| 700 | 1 | |a Kristensen, Bjarne |e verfasserin |4 aut | |
| 700 | 1 | |a Bisgaard, Hans |e verfasserin |4 aut | |
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