Complement-mediated hemolytic uremic syndrome : a diagnostic approach
Complement-mediated hemolytic uremic syndrome (a-HUS), an uncommon variant of thrombotic microangiopathy, is characterized by hemolytic anemia, thrombocytopenia and renal impairment. This disorder might be inherited or/and acquired and leads to dysregulation of the alternative complement pathway at the endothelial cell surface and formation of microvascular thrombi. The differential diagnosis includes other forms of hemolytic syndrome (eg. Shiga-toxin-producing E.coli or S. dysenteriae -associated HUS - STEC-HUS), thrombotic thrombocytopenic purpura (TTP) and congenital errors of vitamin B12 metabolism. The diagnostic approach is presented below.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:72 |
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| Enthalten in: |
Wiadomosci lekarskie (Warsaw, Poland : 1960) - 72(2019), 11 cz 2 vom: 01., Seite 2239-2244 |
| Sprache: |
Polnisch |
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| Beteiligte Personen: |
Wieliczko, Monika [VerfasserIn] |
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| Anmerkungen: |
Date Completed 02.01.2020 Date Revised 08.01.2020 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM304613347 |
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| 520 | |a Complement-mediated hemolytic uremic syndrome (a-HUS), an uncommon variant of thrombotic microangiopathy, is characterized by hemolytic anemia, thrombocytopenia and renal impairment. This disorder might be inherited or/and acquired and leads to dysregulation of the alternative complement pathway at the endothelial cell surface and formation of microvascular thrombi. The differential diagnosis includes other forms of hemolytic syndrome (eg. Shiga-toxin-producing E.coli or S. dysenteriae -associated HUS - STEC-HUS), thrombotic thrombocytopenic purpura (TTP) and congenital errors of vitamin B12 metabolism. The diagnostic approach is presented below | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a complement-mediated hemolytic uremic syndrome | |
| 650 | 4 | |a alternative complement pathway dysregulation | |
| 650 | 4 | |a thrombotic microangiopathy | |
| 650 | 4 | |a thrombotic thrombocytopenic purpura | |
| 650 | 4 | |a Shiga-toxin-producing E. coli | |
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