Acrylamide grafted neem (Azadirachta indica) gum polymer : Screening and exploration as a drug release retardant for tablet formulation
Copyright © 2019 Elsevier Ltd. All rights reserved..
The study was initiated with the intent to synthesize acrylamide grafted neem gum polymer (AAm-g-NG), and screen its drug release retardation ability both in vitro and in vivo. Different batches (NGP-1 to NGP-9) of tablet formulation were prepared by varying polymer concentration using propranolol HCl and compared with HPMC K100 M and marketed SR tablets. FTIR study proved the grafting phenomenon and showed no incompatibility between AAm-g-NG and propranolol HCl. AAm-g-NG showed significant swelling and water retention capacity than NG. AAm-g-NG was found to be biodegradable and exhibited no toxicity to Artemia salina. After 12 h, NGP-6 showed non-significant (p > 0.05; f2= ∼ 90) percent drug release (80.52 ± 3.41%) compare to marketed formulation (79.65 ± 4.08%). Significant swelling of the matrix caused slower diffusion of the drug. NGP-6 and marketed formulation in rabbits showed the non-significant difference between Cmax and Tmax, hence NGP-6 meets the requirement of sustained-release tablets.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:229 |
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| Enthalten in: |
Carbohydrate polymers - 229(2020) vom: 01. Feb., Seite 115357 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bhagwat, Durgacharan A [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 20.04.2020 Date Revised 20.04.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.carbpol.2019.115357 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM304277363 |
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| 245 | 1 | 0 | |a Acrylamide grafted neem (Azadirachta indica) gum polymer |b Screening and exploration as a drug release retardant for tablet formulation |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Elsevier Ltd. All rights reserved. | ||
| 520 | |a The study was initiated with the intent to synthesize acrylamide grafted neem gum polymer (AAm-g-NG), and screen its drug release retardation ability both in vitro and in vivo. Different batches (NGP-1 to NGP-9) of tablet formulation were prepared by varying polymer concentration using propranolol HCl and compared with HPMC K100 M and marketed SR tablets. FTIR study proved the grafting phenomenon and showed no incompatibility between AAm-g-NG and propranolol HCl. AAm-g-NG showed significant swelling and water retention capacity than NG. AAm-g-NG was found to be biodegradable and exhibited no toxicity to Artemia salina. After 12 h, NGP-6 showed non-significant (p > 0.05; f2= ∼ 90) percent drug release (80.52 ± 3.41%) compare to marketed formulation (79.65 ± 4.08%). Significant swelling of the matrix caused slower diffusion of the drug. NGP-6 and marketed formulation in rabbits showed the non-significant difference between Cmax and Tmax, hence NGP-6 meets the requirement of sustained-release tablets | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acetonitrile (PubChem CID: 16211559) | |
| 650 | 4 | |a Acrylamide | |
| 650 | 4 | |a Acrylamide (PubChem CID: 5679) | |
| 650 | 4 | |a Aerosil (PubChem CID: 24261) | |
| 650 | 4 | |a Grafting | |
| 650 | 4 | |a Lactose (PubChem CID: 84571) | |
| 650 | 4 | |a Methanol (PubChem CID: 887) | |
| 650 | 4 | |a Microcrystalline cellulose (PubChem CID: 14055602) | |
| 650 | 4 | |a Neem gum | |
| 650 | 4 | |a Polysaccharides | |
| 650 | 4 | |a Propranolol HCl (PubChem CID: 62822) | |
| 650 | 4 | |a Sustained release | |
| 650 | 7 | |a Delayed-Action Preparations |2 NLM | |
| 650 | 7 | |a Plant Gums |2 NLM | |
| 650 | 7 | |a Tablets |2 NLM | |
| 650 | 7 | |a Acrylamide |2 NLM | |
| 650 | 7 | |a 20R035KLCI |2 NLM | |
| 700 | 1 | |a Kolekar, Vandana R |e verfasserin |4 aut | |
| 700 | 1 | |a Nadaf, Sameer J |e verfasserin |4 aut | |
| 700 | 1 | |a Choudhari, Prafulla B |e verfasserin |4 aut | |
| 700 | 1 | |a More, Harinath N |e verfasserin |4 aut | |
| 700 | 1 | |a Killedar, Suresh G |e verfasserin |4 aut | |
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