High-throughput dense reconstruction of cell lineages
The first meeting exclusively dedicated to the 'High-throughput dense reconstruction of cell lineages' took place at Janelia Research Campus (Howard Hughes Medical Institute) from 14 to 18 April 2019. Organized by Tzumin Lee, Connie Cepko, Jorge Garcia-Marques and Isabel Espinosa-Medina, this meeting echoed the recent eruption of new tools that allow the reconstruction of lineages based on the phylogenetic analysis of DNA mutations induced during development. Combined with single-cell RNA sequencing, these tools promise to solve the lineage of complex model organisms at single-cell resolution. Here, we compile the conference consensus on the technological and computational challenges emerging from the use of the new strategies, as well as potential solutions.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
|---|---|
| Enthalten in: |
Open biology - 9(2019), 12 vom: 31. Dez., Seite 190229 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Espinosa-Medina, Isabel [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
CRISPR/Cas9 |
|---|
| Anmerkungen: |
Date Completed 05.06.2020 Date Revised 27.10.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1098/rsob.190229 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM304235962 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM304235962 | ||
| 003 | DE-627 | ||
| 005 | 20231225114546.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1098/rsob.190229 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1014.xml |
| 035 | |a (DE-627)NLM304235962 | ||
| 035 | |a (NLM)31822210 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Espinosa-Medina, Isabel |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a High-throughput dense reconstruction of cell lineages |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 05.06.2020 | ||
| 500 | |a Date Revised 27.10.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The first meeting exclusively dedicated to the 'High-throughput dense reconstruction of cell lineages' took place at Janelia Research Campus (Howard Hughes Medical Institute) from 14 to 18 April 2019. Organized by Tzumin Lee, Connie Cepko, Jorge Garcia-Marques and Isabel Espinosa-Medina, this meeting echoed the recent eruption of new tools that allow the reconstruction of lineages based on the phylogenetic analysis of DNA mutations induced during development. Combined with single-cell RNA sequencing, these tools promise to solve the lineage of complex model organisms at single-cell resolution. Here, we compile the conference consensus on the technological and computational challenges emerging from the use of the new strategies, as well as potential solutions | ||
| 650 | 4 | |a Consensus Development Conference | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a CRISPR/Cas9 | |
| 650 | 4 | |a dynamic barcoding | |
| 650 | 4 | |a genetic switch | |
| 650 | 4 | |a phylogenetic lineage reconstruction | |
| 650 | 4 | |a scRNA-Seq | |
| 700 | 1 | |a Garcia-Marques, Jorge |e verfasserin |4 aut | |
| 700 | 1 | |a Cepko, Connie |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Tzumin |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Open biology |d 2011 |g 9(2019), 12 vom: 31. Dez., Seite 190229 |w (DE-627)NLM218188943 |x 2046-2441 |7 nnns |
| 773 | 1 | 8 | |g volume:9 |g year:2019 |g number:12 |g day:31 |g month:12 |g pages:190229 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1098/rsob.190229 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 9 |j 2019 |e 12 |b 31 |c 12 |h 190229 | ||