Ultrafiltration Rate, Residual Kidney Function, and Survival Among Patients Treated With Reduced-Frequency Hemodialysis
Published by Elsevier Inc..
RATIONALE & OBJECTIVE: Patients receiving twice-weekly or less-frequent hemodialysis (HD) may need to undergo higher ultrafiltration rates (UFRs) to maintain acceptable fluid balance. We hypothesized that higher UFRs are associated with faster decline in residual kidney function (RKF) and a higher rate of mortality.
STUDY DESIGN: Retrospective cohort study.
SETTING & PARTICIPANTS: 1,524 patients with kidney failure who initiated maintenance HD at a frequency of twice or less per week for at least 6 consecutive weeks at some time between 2007 and 2011 and for whom baseline data for UFR and renal urea clearance were available.
PREDICTOR: Average UFR during the first patient-quarter during less-frequent HD (<6, 6-<10, 10-<13, and≥13mL/h/kg).
OUTCOME: Time to all-cause and cardiovascular death, slope of decline in RKF during the first year after initiation of less-frequent HD (with slopes above the median categorized as rapid decline).
ANALYTICAL APPROACH: Cox proportional hazards regression for time to death and logistic regression for the analysis of rapid decline in RKF.
RESULTS: Among 1,524 patients, higher UFR was associated with higher all-cause mortality; HRs were 1.43 (95% CI, 1.09-1.88), 1.51 (95% CI, 1.08-2.10), and 1.76 (95% CI, 1.23-2.53) for UFR of 6 to<10, 10 to<13, and≥13mL/h/kg, respectively (reference: UFR < 6mL/h/kg). Higher UFR was also associated with higher cardiovascular mortality. Baseline RKF modified the association between UFR and mortality; the association was attenuated among patients with renal urea clearance≥5mL/min/1.73m2. Higher UFR had a graded association with rapid decline in RKF; ORs were 1.73 (95% CI, 1.18-2.55), 1.89 (95% CI, 1.12-3.17), and 2.75 (95% CI, 1.46-5.18) at UFRs of 6 to<10, 10 to<13, and≥13mL/h/kg, respectively (reference: UFR < 6mL/h/kg).
LIMITATIONS: Residual confounding from unobserved differences across exposure categories.
CONCLUSIONS: Higher UFR was associated with worse outcomes, including shorter survival and more rapid loss of RKF, among patients receiving regular HD treatments at a frequency of twice or less per week.
| Errataetall: |
CommentIn: Am J Kidney Dis. 2020 Mar;75(3):322-324. - PMID 31959370 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:75 |
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| Enthalten in: |
American journal of kidney diseases : the official journal of the National Kidney Foundation - 75(2020), 3 vom: 22. März, Seite 342-350 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Yu-Ji [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 30.04.2020 Date Revised 02.03.2021 published: Print-Electronic CommentIn: Am J Kidney Dis. 2020 Mar;75(3):322-324. - PMID 31959370 Citation Status MEDLINE |
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| doi: |
10.1053/j.ajkd.2019.08.019 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM304152188 |
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| 041 | |a eng | ||
| 100 | 1 | |a Lee, Yu-Ji |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Ultrafiltration Rate, Residual Kidney Function, and Survival Among Patients Treated With Reduced-Frequency Hemodialysis |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 30.04.2020 | ||
| 500 | |a Date Revised 02.03.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Am J Kidney Dis. 2020 Mar;75(3):322-324. - PMID 31959370 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Published by Elsevier Inc. | ||
| 520 | |a RATIONALE & OBJECTIVE: Patients receiving twice-weekly or less-frequent hemodialysis (HD) may need to undergo higher ultrafiltration rates (UFRs) to maintain acceptable fluid balance. We hypothesized that higher UFRs are associated with faster decline in residual kidney function (RKF) and a higher rate of mortality | ||
| 520 | |a STUDY DESIGN: Retrospective cohort study | ||
| 520 | |a SETTING & PARTICIPANTS: 1,524 patients with kidney failure who initiated maintenance HD at a frequency of twice or less per week for at least 6 consecutive weeks at some time between 2007 and 2011 and for whom baseline data for UFR and renal urea clearance were available | ||
| 520 | |a PREDICTOR: Average UFR during the first patient-quarter during less-frequent HD (<6, 6-<10, 10-<13, and≥13mL/h/kg) | ||
| 520 | |a OUTCOME: Time to all-cause and cardiovascular death, slope of decline in RKF during the first year after initiation of less-frequent HD (with slopes above the median categorized as rapid decline) | ||
| 520 | |a ANALYTICAL APPROACH: Cox proportional hazards regression for time to death and logistic regression for the analysis of rapid decline in RKF | ||
| 520 | |a RESULTS: Among 1,524 patients, higher UFR was associated with higher all-cause mortality; HRs were 1.43 (95% CI, 1.09-1.88), 1.51 (95% CI, 1.08-2.10), and 1.76 (95% CI, 1.23-2.53) for UFR of 6 to<10, 10 to<13, and≥13mL/h/kg, respectively (reference: UFR < 6mL/h/kg). Higher UFR was also associated with higher cardiovascular mortality. Baseline RKF modified the association between UFR and mortality; the association was attenuated among patients with renal urea clearance≥5mL/min/1.73m2. Higher UFR had a graded association with rapid decline in RKF; ORs were 1.73 (95% CI, 1.18-2.55), 1.89 (95% CI, 1.12-3.17), and 2.75 (95% CI, 1.46-5.18) at UFRs of 6 to<10, 10 to<13, and≥13mL/h/kg, respectively (reference: UFR < 6mL/h/kg) | ||
| 520 | |a LIMITATIONS: Residual confounding from unobserved differences across exposure categories | ||
| 520 | |a CONCLUSIONS: Higher UFR was associated with worse outcomes, including shorter survival and more rapid loss of RKF, among patients receiving regular HD treatments at a frequency of twice or less per week | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 4 | |a Ultrafiltration rate (UFR) | |
| 650 | 4 | |a cardiovascular death | |
| 650 | 4 | |a dialysis intensity | |
| 650 | 4 | |a dialysis prescription | |
| 650 | 4 | |a end-stage renal disease (ESRD) | |
| 650 | 4 | |a hemodialysis (HD) | |
| 650 | 4 | |a less-frequent HD | |
| 650 | 4 | |a mortality | |
| 650 | 4 | |a residual kidney function (RKF) | |
| 650 | 4 | |a residual renal function (RRF) | |
| 650 | 4 | |a twice-weekly dialysis | |
| 700 | 1 | |a Okuda, Yusuke |e verfasserin |4 aut | |
| 700 | 1 | |a Sy, John |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Yong Kyu |e verfasserin |4 aut | |
| 700 | 1 | |a Obi, Yoshitsugu |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Seong |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Joline L T |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Rhee, Connie M |e verfasserin |4 aut | |
| 700 | 1 | |a Kalantar-Zadeh, Kamyar |e verfasserin |4 aut | |
| 700 | 1 | |a Streja, Elani |e verfasserin |4 aut | |
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