The impact of low-dose versus high-dose antibiotic prophylaxis regimens on surgical site infection rates after cesarean delivery
OBJECTIVE: The objective of this study was to determine if high-dose antibiotic prophylaxis with cefazolin decreases the risk of surgical site infection (SSI) after a cesarean delivery.
METHODS: We performed a retrospective cohort study of women who underwent a cesarean section. Two preoperative antibiotic regimens were compared: low dose versus high dose. The primary outcome was SSI. A sample size of 343 patients per group was calculated for a 50% reduction in risk for SSI.
RESULTS: Seven hundred and thirty women were included with an incidence of SSI of 5%. Women who received the high-dose antibiotic regimen had lower rates of risk factors for SSI. The only exception was skin incision closure with staples. The rate of SSI did not differ between the low-dose and high-dose groups, even after adjusting for confounding variables [aOR 1.78, 95% CI (0.82-3.9)].
CONCLUSIONS: Higher doses of antibiotic prophylaxis did not decrease the rates of SSI after cesarean delivery.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:301 |
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| Enthalten in: |
Archives of gynecology and obstetrics - 301(2020), 1 vom: 05. Jan., Seite 69-73 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
La Rosa, Mauricio [VerfasserIn] |
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| Links: |
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| Themen: |
Antibiotics |
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| Anmerkungen: |
Date Completed 08.07.2020 Date Revised 01.09.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00404-019-05370-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM304129798 |
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| 245 | 1 | 4 | |a The impact of low-dose versus high-dose antibiotic prophylaxis regimens on surgical site infection rates after cesarean delivery |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 08.07.2020 | ||
| 500 | |a Date Revised 01.09.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: The objective of this study was to determine if high-dose antibiotic prophylaxis with cefazolin decreases the risk of surgical site infection (SSI) after a cesarean delivery | ||
| 520 | |a METHODS: We performed a retrospective cohort study of women who underwent a cesarean section. Two preoperative antibiotic regimens were compared: low dose versus high dose. The primary outcome was SSI. A sample size of 343 patients per group was calculated for a 50% reduction in risk for SSI | ||
| 520 | |a RESULTS: Seven hundred and thirty women were included with an incidence of SSI of 5%. Women who received the high-dose antibiotic regimen had lower rates of risk factors for SSI. The only exception was skin incision closure with staples. The rate of SSI did not differ between the low-dose and high-dose groups, even after adjusting for confounding variables [aOR 1.78, 95% CI (0.82-3.9)] | ||
| 520 | |a CONCLUSIONS: Higher doses of antibiotic prophylaxis did not decrease the rates of SSI after cesarean delivery | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Antibiotics | |
| 650 | 4 | |a Cesarean | |
| 650 | 4 | |a Infection | |
| 650 | 4 | |a Pregnancy | |
| 650 | 4 | |a Prophylaxis | |
| 650 | 4 | |a Wound | |
| 700 | 1 | |a Omere, Chasey |e verfasserin |4 aut | |
| 700 | 1 | |a Redfern, Tiffany |e verfasserin |4 aut | |
| 700 | 1 | |a Abdelwahab, Mahmoud |e verfasserin |4 aut | |
| 700 | 1 | |a Spencer, Nicholas |e verfasserin |4 aut | |
| 700 | 1 | |a Villarreal, Josephine |e verfasserin |4 aut | |
| 700 | 1 | |a Olson, Gayle |e verfasserin |4 aut | |
| 700 | 1 | |a Saade, George R |e verfasserin |4 aut | |
| 700 | 1 | |a Saad, Antonio F |e verfasserin |4 aut | |
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