Leukocyte telomere length in patients with myotonic dystrophy type I : a pilot study
© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association..
Myotonic dystrophy type I (DM1) is an autosomal dominant disease of which clinical manifestations resemble premature aging. We evaluated the contribution of telomere length in pathogenesis in 361 DM1 patients (12 with serial measurements) and 223 unaffected relative controls using qPCR assay. While no differences in baseline leukocyte relative telomere length (RTL) was noted, the data suggested an accelerated RTL attrition in DM1 (discovery cohort: T/S change/year = -0.013 in DM1 vs. -0.005 in controls, P = 0.04); similar trend was noted in validation cohort. Further investigations are needed to examine the role of TL in the pathophysiology of DM1.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
Annals of clinical and translational neurology - 7(2020), 1 vom: 01. Jan., Seite 126-131 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Youjin [VerfasserIn] |
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| Anmerkungen: |
Date Completed 01.02.2021 Date Revised 01.02.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/acn3.50954 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM304099244 |
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| 245 | 1 | 0 | |a Leukocyte telomere length in patients with myotonic dystrophy type I |b a pilot study |
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| 520 | |a © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. | ||
| 520 | |a Myotonic dystrophy type I (DM1) is an autosomal dominant disease of which clinical manifestations resemble premature aging. We evaluated the contribution of telomere length in pathogenesis in 361 DM1 patients (12 with serial measurements) and 223 unaffected relative controls using qPCR assay. While no differences in baseline leukocyte relative telomere length (RTL) was noted, the data suggested an accelerated RTL attrition in DM1 (discovery cohort: T/S change/year = -0.013 in DM1 vs. -0.005 in controls, P = 0.04); similar trend was noted in validation cohort. Further investigations are needed to examine the role of TL in the pathophysiology of DM1 | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Fernández-Torrón, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Alsaggaf, Rotana |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia-Puga, Mikel |e verfasserin |4 aut | |
| 700 | 1 | |a Dagnall, Casey L |e verfasserin |4 aut | |
| 700 | 1 | |a Hicks, Belynda |e verfasserin |4 aut | |
| 700 | 1 | |a Thompson, Mone't |e verfasserin |4 aut | |
| 700 | 1 | |a Matheu Fernandez, Ander |e verfasserin |4 aut | |
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| 700 | 1 | |a Lopez de Munain, Adolfo |e verfasserin |4 aut | |
| 700 | 1 | |a Gadalla, Shahinaz M |e verfasserin |4 aut | |
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