Synaptic control of spinal GRPR+ neurons by local and long-range inhibitory inputs
Spinal gastrin-releasing peptide receptor-expressing (GRPR+) neurons play an essential role in itch signal processing. However, the circuit mechanisms underlying the modulation of spinal GRPR+ neurons by direct local and long-range inhibitory inputs remain elusive. Using viral tracing and electrophysiological approaches, we dissected the neural circuits underlying the inhibitory control of spinal GRPR+ neurons. We found that spinal galanin+ GABAergic neurons form inhibitory synapses with GRPR+ neurons in the spinal cord and play an important role in gating the GRPR+ neuron-dependent itch signaling pathway. Spinal GRPR+ neurons also receive inhibitory inputs from local neurons expressing neuronal nitric oxide synthase (nNOS). Moreover, spinal GRPR+ neurons are gated by strong inhibitory inputs from the rostral ventromedial medulla. Thus, both local and long-range inhibitory inputs could play important roles in gating itch processing in the spinal cord by directly modulating the activity of spinal GRPR+ neurons.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:116 |
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| Enthalten in: |
Proceedings of the National Academy of Sciences of the United States of America - 116(2019), 52 vom: 26. Dez., Seite 27011-27017 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Ming-Zhe [VerfasserIn] |
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| Links: |
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| Themen: |
Galanin+ GABAergic neurons |
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| Anmerkungen: |
Date Revised 05.12.2022 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1073/pnas.1905658116 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM304084174 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Spinal gastrin-releasing peptide receptor-expressing (GRPR+) neurons play an essential role in itch signal processing. However, the circuit mechanisms underlying the modulation of spinal GRPR+ neurons by direct local and long-range inhibitory inputs remain elusive. Using viral tracing and electrophysiological approaches, we dissected the neural circuits underlying the inhibitory control of spinal GRPR+ neurons. We found that spinal galanin+ GABAergic neurons form inhibitory synapses with GRPR+ neurons in the spinal cord and play an important role in gating the GRPR+ neuron-dependent itch signaling pathway. Spinal GRPR+ neurons also receive inhibitory inputs from local neurons expressing neuronal nitric oxide synthase (nNOS). Moreover, spinal GRPR+ neurons are gated by strong inhibitory inputs from the rostral ventromedial medulla. Thus, both local and long-range inhibitory inputs could play important roles in gating itch processing in the spinal cord by directly modulating the activity of spinal GRPR+ neurons | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a galanin+ GABAergic neurons | |
| 650 | 4 | |a gating itch processing | |
| 650 | 4 | |a inhibitory control | |
| 650 | 4 | |a rostral ventromedial medulla | |
| 650 | 4 | |a spinal GRPR+ neurons | |
| 700 | 1 | |a Chen, Xiao-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Tong-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Meng |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xin-Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yu-Zhuo |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Qiang |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Yan-Gang |e verfasserin |4 aut | |
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