Cervical, anal and oral human papillomavirus (HPV) infection in young women : A case control study between women with perinatally HIV infection and women with non-perinatally HIV infection
Copyright © 2019 Elsevier B.V. All rights reserved..
OBJECTIVES: HPV infection may differ in women who are HIV-positive since birth (perinatally infected, P-HIV) and those who acquire HIV later in life (non-perinatally infected, NP-HIV). We assessed the HPV prevalence in relation to the HIV acquisition route and HPV vaccination status.
STUDY DESIGN: Case control study comparing 22 P-HIV with 22 NP-HIV patients. Cervical, anal and oral specimen were collected for HPV PCRs. The primary outcome was the prevalence of cervical, oral and anal HPV in P-HIV and NP-HIV patients. The secondary outcome was to identify risk factors for HPV infection. Comparative statistics for two independent groups, univariate and multivariable logistic regression analyses were used.
RESULTS: There were no differences between perinatally and non-perinatally infected women. Cervical dysplasia was found in 12/44 (27 %) patients and high-risk HPV (hrHPV) in 30 % of cervical (of which 89 % were hrHPV other than 16 and 18), in 3 % of oral and 65 % of anal specimens. All woman were using combined antiretroviral therapy (cART) and 64 % had HIVRNA < 20 cp/ml. A CD4 count <350/mm³ was associated with cytological abnormalities (OR: 13.52, p = 0.002) and with cervical HPV (OR: 6.11; p = 0.04); anal HPV was associated with a previous cervical dysplasia and concomitant cervical HPV infection. None of thirteen vaccinated patients had a 6/11/16/18 HPV infection.
CONCLUSION: In this small series of women under cART, we did not observe a difference in HPV infection in relation to the route of HIV acquisition. The high prevalence of hrHPV other than 16 and 18 support the use of a 9-valent vaccine.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:244 |
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| Enthalten in: |
European journal of obstetrics, gynecology, and reproductive biology - 244(2020) vom: 01. Jan., Seite 114-119 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gilles, Christine [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 12.11.2020 Date Revised 12.11.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ejogrb.2019.11.022 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM303876085 |
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| 100 | 1 | |a Gilles, Christine |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Cervical, anal and oral human papillomavirus (HPV) infection in young women |b A case control study between women with perinatally HIV infection and women with non-perinatally HIV infection |
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| 500 | |a Date Completed 12.11.2020 | ||
| 500 | |a Date Revised 12.11.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Elsevier B.V. All rights reserved. | ||
| 520 | |a OBJECTIVES: HPV infection may differ in women who are HIV-positive since birth (perinatally infected, P-HIV) and those who acquire HIV later in life (non-perinatally infected, NP-HIV). We assessed the HPV prevalence in relation to the HIV acquisition route and HPV vaccination status | ||
| 520 | |a STUDY DESIGN: Case control study comparing 22 P-HIV with 22 NP-HIV patients. Cervical, anal and oral specimen were collected for HPV PCRs. The primary outcome was the prevalence of cervical, oral and anal HPV in P-HIV and NP-HIV patients. The secondary outcome was to identify risk factors for HPV infection. Comparative statistics for two independent groups, univariate and multivariable logistic regression analyses were used | ||
| 520 | |a RESULTS: There were no differences between perinatally and non-perinatally infected women. Cervical dysplasia was found in 12/44 (27 %) patients and high-risk HPV (hrHPV) in 30 % of cervical (of which 89 % were hrHPV other than 16 and 18), in 3 % of oral and 65 % of anal specimens. All woman were using combined antiretroviral therapy (cART) and 64 % had HIVRNA < 20 cp/ml. A CD4 count <350/mm³ was associated with cytological abnormalities (OR: 13.52, p = 0.002) and with cervical HPV (OR: 6.11; p = 0.04); anal HPV was associated with a previous cervical dysplasia and concomitant cervical HPV infection. None of thirteen vaccinated patients had a 6/11/16/18 HPV infection | ||
| 520 | |a CONCLUSION: In this small series of women under cART, we did not observe a difference in HPV infection in relation to the route of HIV acquisition. The high prevalence of hrHPV other than 16 and 18 support the use of a 9-valent vaccine | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a HIV | |
| 650 | 4 | |a HPV | |
| 650 | 4 | |a Vaccination | |
| 650 | 4 | |a Young adult | |
| 700 | 1 | |a Buljubasic, Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Konopnicki, Déborah |e verfasserin |4 aut | |
| 700 | 1 | |a Manigart, Yannick |e verfasserin |4 aut | |
| 700 | 1 | |a Barlow, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Rozenberg, Serge |e verfasserin |4 aut | |
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