Genotypic resistance profiles of HIV-2-infected patients from Cape Verde failing first-line antiretroviral therapy
: The pol gene from HIV-2-infected patients from Cape Verde experiencing virologic failure was sequenced and drug resistance mutations were determined. Most patients were taking a first-line regimen of zidovudine (AZT), lamivudine (3TC) and lopinavir/ritonavir (LPV/r). Resistance mutations were found in most patients (11/17; 64.7%) especially I82F (4/7; 57.1%) and M184V (10/17; 58.8%). Resistance to all reverse transcriptase and protease inhibitors was found in 58.8% (10/17) of the patients. Integrase inhibitors are warranted to treat these patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
AIDS (London, England) - 34(2020), 3 vom: 01. März, Seite 483-486 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Moranguinho, Inês [VerfasserIn] |
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| Links: |
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| Themen: |
2494G1JF75 |
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| Anmerkungen: |
Date Completed 08.02.2021 Date Revised 08.02.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1097/QAD.0000000000002431 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM303665513 |
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| 245 | 1 | 0 | |a Genotypic resistance profiles of HIV-2-infected patients from Cape Verde failing first-line antiretroviral therapy |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a : The pol gene from HIV-2-infected patients from Cape Verde experiencing virologic failure was sequenced and drug resistance mutations were determined. Most patients were taking a first-line regimen of zidovudine (AZT), lamivudine (3TC) and lopinavir/ritonavir (LPV/r). Resistance mutations were found in most patients (11/17; 64.7%) especially I82F (4/7; 57.1%) and M184V (10/17; 58.8%). Resistance to all reverse transcriptase and protease inhibitors was found in 58.8% (10/17) of the patients. Integrase inhibitors are warranted to treat these patients | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Borrego, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Gonçalves, Fátima |e verfasserin |4 aut | |
| 700 | 1 | |a Gomes, Perpétua |e verfasserin |4 aut | |
| 700 | 1 | |a Rocha, José |e verfasserin |4 aut | |
| 700 | 1 | |a Barreto, Jorge |e verfasserin |4 aut | |
| 700 | 1 | |a Taveira, Nuno |e verfasserin |4 aut | |
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