Lipase is associated with deltamethrin resistance in Culex pipiens pallens
The wide application of pyrethroids has led to the rapid development of insecticide resistance in mosquitoes, leading to a rise in mosquito-borne diseases. We previously identified five differentially expressed lipase family genes upon evaluating the transcriptomes of deltamethrin-resistant and deltamethrin-susceptible strains of Culex pipiens pallens. Herein, the gene expression levels were verified by quantitative real-time PCR, and two lipase family genes, lipase A and pancreatic triacylglycerol lipase A, were chosen for further investigations. Using cell viability assays and Centers for Disease Control and Prevention bottle bioassays, lipase A was found to increase the resistance of mosquitoes against deltamethrin both in vitro and in vivo. Our findings indicate that lipase A is involved in conferring deltamethrin resistance in Cx. pipiens pallens.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:119 |
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| Enthalten in: |
Parasitology research - 119(2020), 1 vom: 23. Jan., Seite 23-30 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hu, Hong-Xia [VerfasserIn] |
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| Links: |
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| Themen: |
2JTS8R821G |
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| Anmerkungen: |
Date Completed 06.03.2020 Date Revised 06.03.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00436-019-06489-2 |
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| funding: |
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NLM303630302 |
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| 520 | |a The wide application of pyrethroids has led to the rapid development of insecticide resistance in mosquitoes, leading to a rise in mosquito-borne diseases. We previously identified five differentially expressed lipase family genes upon evaluating the transcriptomes of deltamethrin-resistant and deltamethrin-susceptible strains of Culex pipiens pallens. Herein, the gene expression levels were verified by quantitative real-time PCR, and two lipase family genes, lipase A and pancreatic triacylglycerol lipase A, were chosen for further investigations. Using cell viability assays and Centers for Disease Control and Prevention bottle bioassays, lipase A was found to increase the resistance of mosquitoes against deltamethrin both in vitro and in vivo. Our findings indicate that lipase A is involved in conferring deltamethrin resistance in Cx. pipiens pallens | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Deltamethrin | |
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| 700 | 1 | |a Sun, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Chang-Liang |e verfasserin |4 aut | |
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