PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen's disease (leprosy) endemic area of Brazil
Copyright © 2019 Elsevier GmbH. All rights reserved..
Serological tests for subclinical Mycobacterium leprae infection based on antibodies to phenolic glycolipid-1 (PGL-1) and leprosy IDRI diagnostic-1 (LID-1) have not been compared in HIV-infected and uninfected individuals. PGL-1 seropositivity by ELISA was 6.0 % (21/350) in HIV-infected compared with 29.1 % (102/350) in HIV-uninfected individuals (p < 0.001); LID-1 seropositivity was 45.4 % (159/350) in HIV-infected compared with 50.3 % (153/304) in HIV-uninfected individuals (p = 0.21). In HIV-infected individuals, LID-1 but not PGL-1 antibody levels were inversely associated with CD4+ cell count (p = 0.02). These differential associations of HIV infection and CD4 count with PGL-1 and LID-1 have implications for M leprae immunodiagnostic tools and require replication.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:225 |
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| Enthalten in: |
Immunobiology - 225(2020), 1 vom: 10. Jan., Seite 151866 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Madureira, Brunela Pitanga [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies, Bacterial |
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| Anmerkungen: |
Date Completed 07.01.2021 Date Revised 07.01.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.imbio.2019.11.001 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM303601582 |
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| 100 | 1 | |a Madureira, Brunela Pitanga |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen's disease (leprosy) endemic area of Brazil |
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| 500 | |a Date Revised 07.01.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Elsevier GmbH. All rights reserved. | ||
| 520 | |a Serological tests for subclinical Mycobacterium leprae infection based on antibodies to phenolic glycolipid-1 (PGL-1) and leprosy IDRI diagnostic-1 (LID-1) have not been compared in HIV-infected and uninfected individuals. PGL-1 seropositivity by ELISA was 6.0 % (21/350) in HIV-infected compared with 29.1 % (102/350) in HIV-uninfected individuals (p < 0.001); LID-1 seropositivity was 45.4 % (159/350) in HIV-infected compared with 50.3 % (153/304) in HIV-uninfected individuals (p = 0.21). In HIV-infected individuals, LID-1 but not PGL-1 antibody levels were inversely associated with CD4+ cell count (p = 0.02). These differential associations of HIV infection and CD4 count with PGL-1 and LID-1 have implications for M leprae immunodiagnostic tools and require replication | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a HIV | |
| 650 | 4 | |a LID-1 | |
| 650 | 4 | |a Leprosy | |
| 650 | 4 | |a PGL-1 | |
| 650 | 7 | |a Antibodies, Bacterial |2 NLM | |
| 650 | 7 | |a Antigens, Bacterial |2 NLM | |
| 650 | 7 | |a Glycolipids |2 NLM | |
| 650 | 7 | |a Lipid Droplet Associated Proteins |2 NLM | |
| 650 | 7 | |a phenolic glycolipid I, Mycobacterium leprae |2 NLM | |
| 700 | 1 | |a de Carvalho, Fernanda Marques |e verfasserin |4 aut | |
| 700 | 1 | |a Pessolani, Maria Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Collin, Simon Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Deps, Patrícia Duarte |e verfasserin |4 aut | |
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