To compare intralesional and oral propranolol for treating periorbital and eyelid capillary hemangiomas
Purpose: A pilot randomized control trial to compare the efficacy and side effects of intralesional and oral propranolol in periorbital and eyelid capillary hemangiomas.
Methods: Twenty patients were prospectively randomized to two groups of ten each. Group 1 was initiated on oral propranolol 1 mg/kg/day titrated to final dose of 3 mg/kg/day over 1 week which was continued for 6 months and then tapered over 1 week; Group 2 received 3 doses of direct intralesional propranolol hydrochloride 1 mg/ml; 0.2 ml/cm 4-6 weeks apart. Hemangioma area and corneal astigmatism were measured.
Results: Within each group at 6 months there was a significant reduction in area (group 1: 83.48 ± 11.67%,P= 0.0019; group 2: 67.78 ± 21.71%,P= 0.0019) and improvement in astigmatism (pre, post: group 1: 2.98D 179.8°, 1.13D @ 179.8°,P= 0.0045; group 2: 1.62D @ 90.16°, 0.75D @ 179.9°,P= 0.0001). There was no difference in area reduction (P = 0.056), change in appearance (P = 0.085), ptosis (P = 0.23) and side effects (lethargy, poor feeding;P= 0.171) between the two groups.
Conclusion: Efficacy and side effects with intralesional propranolol are comparable to oral propranolol for periorbital and eyelid lesions.
| Errataetall: |
CommentIn: Indian J Ophthalmol. 2019 Dec;67(12):1981-1982. - PMID 31755432 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:67 |
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| Enthalten in: |
Indian journal of ophthalmology - 67(2019), 12 vom: 22. Dez., Seite 1974-1980 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mehta, Aditi [VerfasserIn] |
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| Links: |
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| Themen: |
9Y8NXQ24VQ |
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| Anmerkungen: |
Date Completed 10.07.2020 Date Revised 10.07.2020 published: Print CommentIn: Indian J Ophthalmol. 2019 Dec;67(12):1981-1982. - PMID 31755432 Citation Status MEDLINE |
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| doi: |
10.4103/ijo.IJO_59_19 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM303580402 |
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| 100 | 1 | |a Mehta, Aditi |e verfasserin |4 aut | |
| 245 | 1 | 3 | |a To compare intralesional and oral propranolol for treating periorbital and eyelid capillary hemangiomas |
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| 500 | |a Date Completed 10.07.2020 | ||
| 500 | |a Date Revised 10.07.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Indian J Ophthalmol. 2019 Dec;67(12):1981-1982. - PMID 31755432 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Purpose: A pilot randomized control trial to compare the efficacy and side effects of intralesional and oral propranolol in periorbital and eyelid capillary hemangiomas | ||
| 520 | |a Methods: Twenty patients were prospectively randomized to two groups of ten each. Group 1 was initiated on oral propranolol 1 mg/kg/day titrated to final dose of 3 mg/kg/day over 1 week which was continued for 6 months and then tapered over 1 week; Group 2 received 3 doses of direct intralesional propranolol hydrochloride 1 mg/ml; 0.2 ml/cm 4-6 weeks apart. Hemangioma area and corneal astigmatism were measured | ||
| 520 | |a Results: Within each group at 6 months there was a significant reduction in area (group 1: 83.48 ± 11.67%,P= 0.0019; group 2: 67.78 ± 21.71%,P= 0.0019) and improvement in astigmatism (pre, post: group 1: 2.98D 179.8°, 1.13D @ 179.8°,P= 0.0045; group 2: 1.62D @ 90.16°, 0.75D @ 179.9°,P= 0.0001). There was no difference in area reduction (P = 0.056), change in appearance (P = 0.085), ptosis (P = 0.23) and side effects (lethargy, poor feeding;P= 0.171) between the two groups | ||
| 520 | |a Conclusion: Efficacy and side effects with intralesional propranolol are comparable to oral propranolol for periorbital and eyelid lesions | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Capillary hemangioma | |
| 650 | 4 | |a intralesional propranolol | |
| 650 | 4 | |a oral propranolol | |
| 650 | 7 | |a Adrenergic beta-Antagonists |2 NLM | |
| 650 | 7 | |a Propranolol |2 NLM | |
| 650 | 7 | |a 9Y8NXQ24VQ |2 NLM | |
| 700 | 1 | |a Bajaj, Mandeep S |e verfasserin |4 aut | |
| 700 | 1 | |a Pushker, Neelam |e verfasserin |4 aut | |
| 700 | 1 | |a Chawla, Bhavna |e verfasserin |4 aut | |
| 700 | 1 | |a Pujari, Amar |e verfasserin |4 aut | |
| 700 | 1 | |a Grewal, Sartaj S |e verfasserin |4 aut | |
| 700 | 1 | |a Grewal, Satinder Pal Singh |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, Simar Rajan |e verfasserin |4 aut | |
| 700 | 1 | |a Kishore, Alisha |e verfasserin |4 aut | |
| 700 | 1 | |a Yadav, Neha Singh |e verfasserin |4 aut | |
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