Increased Basal Blood Histamine Levels in Patients with Self-Reported Hypersensitivity to Non-Steroidal Anti-Inflammatory Drugs
© 2019 S. Karger AG, Basel..
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) represent one of the most prevalent causes of drug hypersensitivity reactions (DHRs), yet the underlying processes are far from clear. Despite the established role of histamine in allergic reactions, its precise implication in DHRs is elusive.
OBJECTIVES: This study aimed to explore the connection of basal blood histamine levels to the reported NSAID hypersensitivity.
METHODS: Sixteen patients reporting hypersensitivity reactions to a single or multiple NSAIDs and/or paracetamol and 18 healthy volunteers serving as the normal control group enrolled in the study. The medical history was recorded and histamine was quantified spectrophotofluorometrically in whole peripheral blood and plasma.
RESULTS: Compared to the normal group, plasma but not whole blood histamine levels were significantly higher in patients (p < 0.001), mainly in the subgroup reporting hypersensitivity to a single agent (p < 0.001). Plasma histamine levels were significantly correlated with the culprit drug selectivity for cyclooxygenase (COX) isozymes (p < 0.001), with higher levels being obtained in patients reporting reactions to COX-1 than to COX-2 selective inhibitors (p < 0.05).
CONCLUSIONS: The findings provide first evidence connecting basal blood histamine levels to the reported NSAID-triggered DHRs. Prospective studies are expected to decipher the contribution of histamine-associated parameters to the mechanisms underlying DHRs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:181 |
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| Enthalten in: |
International archives of allergy and immunology - 181(2020), 1 vom: 21., Seite 24-30 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kakolyri, Maria [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 13.01.2020 Date Revised 13.01.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1159/000503968 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM303546336 |
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| 100 | 1 | |a Kakolyri, Maria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Increased Basal Blood Histamine Levels in Patients with Self-Reported Hypersensitivity to Non-Steroidal Anti-Inflammatory Drugs |
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| 500 | |a Date Revised 13.01.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2019 S. Karger AG, Basel. | ||
| 520 | |a BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) represent one of the most prevalent causes of drug hypersensitivity reactions (DHRs), yet the underlying processes are far from clear. Despite the established role of histamine in allergic reactions, its precise implication in DHRs is elusive | ||
| 520 | |a OBJECTIVES: This study aimed to explore the connection of basal blood histamine levels to the reported NSAID hypersensitivity | ||
| 520 | |a METHODS: Sixteen patients reporting hypersensitivity reactions to a single or multiple NSAIDs and/or paracetamol and 18 healthy volunteers serving as the normal control group enrolled in the study. The medical history was recorded and histamine was quantified spectrophotofluorometrically in whole peripheral blood and plasma | ||
| 520 | |a RESULTS: Compared to the normal group, plasma but not whole blood histamine levels were significantly higher in patients (p < 0.001), mainly in the subgroup reporting hypersensitivity to a single agent (p < 0.001). Plasma histamine levels were significantly correlated with the culprit drug selectivity for cyclooxygenase (COX) isozymes (p < 0.001), with higher levels being obtained in patients reporting reactions to COX-1 than to COX-2 selective inhibitors (p < 0.05) | ||
| 520 | |a CONCLUSIONS: The findings provide first evidence connecting basal blood histamine levels to the reported NSAID-triggered DHRs. Prospective studies are expected to decipher the contribution of histamine-associated parameters to the mechanisms underlying DHRs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cyclooxygenase inhibitors | |
| 650 | 4 | |a Drug hypersensitivity reactions | |
| 650 | 4 | |a Histamine | |
| 650 | 4 | |a Human peripheral blood | |
| 650 | 4 | |a Non-steroidal anti-inflammatory drugs | |
| 650 | 7 | |a Allergens |2 NLM | |
| 650 | 7 | |a Anti-Inflammatory Agents, Non-Steroidal |2 NLM | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Cyclooxygenase 2 Inhibitors |2 NLM | |
| 650 | 7 | |a Acetaminophen |2 NLM | |
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| 650 | 7 | |a Histamine |2 NLM | |
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| 700 | 1 | |a Strikou, Flora |e verfasserin |4 aut | |
| 700 | 1 | |a Kavallari, Andriana |e verfasserin |4 aut | |
| 700 | 1 | |a Chliva, Caterina |e verfasserin |4 aut | |
| 700 | 1 | |a Makris, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Tiligada, Ekaterini |e verfasserin |4 aut | |
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