The risk of preschool asthma at 2-4 years is not associated with leukocyte telomere length at birth or at 1 year of age
Copyright © 2019. Asia Pacific Association of Allergy, Asthma and Clinical Immunology..
BACKGROUND: Exposure to prenatal stress is associated with offspring allergic-disease development, and oxidative stress may mediate this relationship.
OBJECTIVE: We aimed to evaluate whether leukocyte telomere length (LTL) shortening, a marker for exposure to oxidative stress, in early life is associated with increased risk of asthma development during the preschool period.
METHODS: We assessed the follow-up clinical data of a subgroup from a birth cohort whose LTLs had been measured from cord-blood and 1-year peripheral-blood samples. We examined whether the LTLs would be associated with asthma development at the age of 2-4 years.
RESULTS: The data of 84 subjects were analyzed. LTLs were measured from the cord-blood and 1-year peripheral blood of 75 and 79 subjects, respectively. Among them, 14 subjects (16.7%) developed bronchial asthma between 2-4 years old. Prenatally stressed subjects had marginally increased odds of developing asthma (p = 0.097). There was no significant difference in the odds of preschool-asthma development between the groups with shorter and longer cord-blood LTLs (odds ratio [OR], 0.651; 95% confidence interval [CI], 0.184-2.306) or in the odds between the groups with shorter and longer 1-year peripheral-blood LTLs (OR, 0.448; 95% CI, 0.135-1.483). Finally, subjects with both higher prenatal stress and shorter LTLs did not have significantly higher odds of preschool-asthma development (for cord-blood: OR, 1.242; 95% CI, 0.353-4.368; for 1-year peripheral-blood: OR, 1.451; 95% CI, 0.428-4.919).
CONCLUSION: There was no significant association between early life LTLs and higher risk of bronchial-asthma development during the preschool years.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
|---|---|
| Enthalten in: |
Asia Pacific allergy - 9(2019), 4 vom: 30. Okt., Seite e33 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Suh, Dong In [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Allergy |
|---|
| Anmerkungen: |
Date Revised 11.04.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.5415/apallergy.2019.9.e33 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM303238259 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM303238259 | ||
| 003 | DE-627 | ||
| 005 | 20231226200756.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.5415/apallergy.2019.9.e33 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1010.xml |
| 035 | |a (DE-627)NLM303238259 | ||
| 035 | |a (NLM)31720244 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Suh, Dong In |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The risk of preschool asthma at 2-4 years is not associated with leukocyte telomere length at birth or at 1 year of age |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 11.04.2022 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2019. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. | ||
| 520 | |a BACKGROUND: Exposure to prenatal stress is associated with offspring allergic-disease development, and oxidative stress may mediate this relationship | ||
| 520 | |a OBJECTIVE: We aimed to evaluate whether leukocyte telomere length (LTL) shortening, a marker for exposure to oxidative stress, in early life is associated with increased risk of asthma development during the preschool period | ||
| 520 | |a METHODS: We assessed the follow-up clinical data of a subgroup from a birth cohort whose LTLs had been measured from cord-blood and 1-year peripheral-blood samples. We examined whether the LTLs would be associated with asthma development at the age of 2-4 years | ||
| 520 | |a RESULTS: The data of 84 subjects were analyzed. LTLs were measured from the cord-blood and 1-year peripheral blood of 75 and 79 subjects, respectively. Among them, 14 subjects (16.7%) developed bronchial asthma between 2-4 years old. Prenatally stressed subjects had marginally increased odds of developing asthma (p = 0.097). There was no significant difference in the odds of preschool-asthma development between the groups with shorter and longer cord-blood LTLs (odds ratio [OR], 0.651; 95% confidence interval [CI], 0.184-2.306) or in the odds between the groups with shorter and longer 1-year peripheral-blood LTLs (OR, 0.448; 95% CI, 0.135-1.483). Finally, subjects with both higher prenatal stress and shorter LTLs did not have significantly higher odds of preschool-asthma development (for cord-blood: OR, 1.242; 95% CI, 0.353-4.368; for 1-year peripheral-blood: OR, 1.451; 95% CI, 0.428-4.919) | ||
| 520 | |a CONCLUSION: There was no significant association between early life LTLs and higher risk of bronchial-asthma development during the preschool years | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Allergy | |
| 650 | 4 | |a Asthma | |
| 650 | 4 | |a Bronchial diseases | |
| 650 | 4 | |a Child, Preschool | |
| 650 | 4 | |a Oxidative stress, Telomere shortening | |
| 700 | 1 | |a Kang, Mi-Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Yoon Mee |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Jun-Kyu |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, So-Yeon |e verfasserin |4 aut | |
| 700 | 1 | |a Sheen, Youn Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Kyung Won |e verfasserin |4 aut | |
| 700 | 1 | |a Ahn, Kangmo |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, Soo-Jong |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Asia Pacific allergy |d 2012 |g 9(2019), 4 vom: 30. Okt., Seite e33 |w (DE-627)NLM218656807 |x 2233-8276 |7 nnns |
| 773 | 1 | 8 | |g volume:9 |g year:2019 |g number:4 |g day:30 |g month:10 |g pages:e33 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.5415/apallergy.2019.9.e33 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 9 |j 2019 |e 4 |b 30 |c 10 |h e33 | ||