Association between hepatitis C and B viruses and head and neck squamous cell carcinoma
Copyright © 2019 Elsevier B.V. All rights reserved..
BACKGROUND: Hepatitis B and C viruses are known to be carcinogenic and have been associated with the development of non-Hodgkin's lymphoma as well as hepatocellular carcinoma. The incidence of head and neck cancer is increasing worldwide, and early diagnosis is vital in order to achieve good oncological outcomes.
OBJECTIVES: To investigate the association between chronic hepatitis B and C infection, and head and neck squamous cell carcinoma (HNSCC).
STUDY DESIGN: We performed a retrospective case control study with 774 head and neck squamous cell carcinoma (HNSCC) patients undergoing treatment, and 1518 cancer-free controls undergoing hernia surgery. Hepatitis B and C serologies were tested prior to treatment, and cases and controls were age- and sex-matched before analysing rates of infection.
RESULTS: HNSCC patients were more likely than controls to have evidence of chronic hepatitis B (OR = 2.76; CI 95 %, 1.64-4.64) and hepatitis C (OR = 2.59; 95 % CI, 1.46-4.60) infection. No substantial association was found between hepatitis B and C infection and other known risk factors for head and neck cancer.
CONCLUSIONS: These findings suggest a positive association between both hepatitis B and hepatitis C chronic infection, and HNSCC. More work is needed to establish a causal role, however an awareness of the possibility of increased risk of HNSCC may lead to earlier diagnosis and better outcomes in patients with hepatitis B and C.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:121 |
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| Enthalten in: |
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 121(2019) vom: 01. Dez., Seite 104209 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Donà, Sara [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies, Viral |
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| Anmerkungen: |
Date Completed 23.07.2020 Date Revised 23.07.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jcv.2019.104209 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM303147687 |
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| 245 | 1 | 0 | |a Association between hepatitis C and B viruses and head and neck squamous cell carcinoma |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: Hepatitis B and C viruses are known to be carcinogenic and have been associated with the development of non-Hodgkin's lymphoma as well as hepatocellular carcinoma. The incidence of head and neck cancer is increasing worldwide, and early diagnosis is vital in order to achieve good oncological outcomes | ||
| 520 | |a OBJECTIVES: To investigate the association between chronic hepatitis B and C infection, and head and neck squamous cell carcinoma (HNSCC) | ||
| 520 | |a STUDY DESIGN: We performed a retrospective case control study with 774 head and neck squamous cell carcinoma (HNSCC) patients undergoing treatment, and 1518 cancer-free controls undergoing hernia surgery. Hepatitis B and C serologies were tested prior to treatment, and cases and controls were age- and sex-matched before analysing rates of infection | ||
| 520 | |a RESULTS: HNSCC patients were more likely than controls to have evidence of chronic hepatitis B (OR = 2.76; CI 95 %, 1.64-4.64) and hepatitis C (OR = 2.59; 95 % CI, 1.46-4.60) infection. No substantial association was found between hepatitis B and C infection and other known risk factors for head and neck cancer | ||
| 520 | |a CONCLUSIONS: These findings suggest a positive association between both hepatitis B and hepatitis C chronic infection, and HNSCC. More work is needed to establish a causal role, however an awareness of the possibility of increased risk of HNSCC may lead to earlier diagnosis and better outcomes in patients with hepatitis B and C | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Case-control study | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Head and neck cancer | |
| 650 | 4 | |a Hepatitis B infection | |
| 650 | 4 | |a Hepatitis C infection | |
| 650 | 7 | |a Antibodies, Viral |2 NLM | |
| 700 | 1 | |a Borsetto, Daniele |e verfasserin |4 aut | |
| 700 | 1 | |a Fussey, Jonathan |e verfasserin |4 aut | |
| 700 | 1 | |a Biscaro, Valeria |e verfasserin |4 aut | |
| 700 | 1 | |a Vian, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Spinato, Giacomo |e verfasserin |4 aut | |
| 700 | 1 | |a Menegaldo, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Da Mosto, Maria Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Rigoli, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Polesel, Jerry |e verfasserin |4 aut | |
| 700 | 1 | |a Boscolo-Rizzo, Paolo |e verfasserin |4 aut | |
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