Interfering with airway nerves in cough associated with asthma
Copyright © 2019 Elsevier Ltd. All rights reserved..
Cough is a troublesome and often refractory symptom of asthma, which is associated with poor control of disease. The pathogenesis of asthmatic cough has mainly been attributed to bronchoconstriction, but recent evidence indicate that cough reflex hypersensitivity or neuronal dysfunction is a feature of asthma, even in those with mild stable disease. This is likely resistant to the mainstay treatment ICS/LABA which inhibits classic asthmatic response. Such refractory cough might manifest more predominantly in the day-time rather than night-time. Treatment options of such refractory cough or cough reflex hypersensitivity in asthma targeting the nerves (LTRAs, tiotropium, and potentially bronchial thermoplasty) are discussed.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:59 |
|---|---|
| Enthalten in: |
Pulmonary pharmacology & therapeutics - 59(2019) vom: 01. Dez., Seite 101854 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Niimi, Akio [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Airway nerve |
|---|
| Anmerkungen: |
Date Completed 03.09.2020 Date Revised 03.09.2020 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.pupt.2019.101854 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM302873562 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM302873562 | ||
| 003 | DE-627 | ||
| 005 | 20231225111636.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.pupt.2019.101854 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1009.xml |
| 035 | |a (DE-627)NLM302873562 | ||
| 035 | |a (NLM)31683030 | ||
| 035 | |a (PII)S1094-5539(19)30172-5 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Niimi, Akio |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Interfering with airway nerves in cough associated with asthma |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 03.09.2020 | ||
| 500 | |a Date Revised 03.09.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Cough is a troublesome and often refractory symptom of asthma, which is associated with poor control of disease. The pathogenesis of asthmatic cough has mainly been attributed to bronchoconstriction, but recent evidence indicate that cough reflex hypersensitivity or neuronal dysfunction is a feature of asthma, even in those with mild stable disease. This is likely resistant to the mainstay treatment ICS/LABA which inhibits classic asthmatic response. Such refractory cough might manifest more predominantly in the day-time rather than night-time. Treatment options of such refractory cough or cough reflex hypersensitivity in asthma targeting the nerves (LTRAs, tiotropium, and potentially bronchial thermoplasty) are discussed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Airway nerve | |
| 650 | 4 | |a Asthma | |
| 650 | 4 | |a Bronchial thermoplasty | |
| 650 | 4 | |a Chronic cough | |
| 650 | 4 | |a Cough reflex sensitivity | |
| 650 | 4 | |a Tiotropium | |
| 650 | 7 | |a Anti-Asthmatic Agents |2 NLM | |
| 650 | 7 | |a Antitussive Agents |2 NLM | |
| 700 | 1 | |a Fukumitsu, Kensuke |e verfasserin |4 aut | |
| 700 | 1 | |a Takeda, Norihisa |e verfasserin |4 aut | |
| 700 | 1 | |a Kanemitsu, Yoshihiro |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pulmonary pharmacology & therapeutics |d 1997 |g 59(2019) vom: 01. Dez., Seite 101854 |w (DE-627)NLM092899625 |x 1522-9629 |7 nnns |
| 773 | 1 | 8 | |g volume:59 |g year:2019 |g day:01 |g month:12 |g pages:101854 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.pupt.2019.101854 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 59 |j 2019 |b 01 |c 12 |h 101854 | ||