Prognostic significance of body mass index and prognostic nutritional index in stage II/III gastric cancer
Copyright © 2019 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved..
INTRODUCTION: Preoperative body weight and nutritional status are related to prognosis in patients with gastric cancer; however, the prognostic impact of postoperative in these variables is unclear. We aimed to investigate the association of preoperative/postoperative body mass index (BMI) and prognostic nutritional index (PNI) with prognosis in patients with gastric cancer.
MATERIALS AND METHODS: We retrospectively 1868 patients with stage II/III gastric cancer treated with gastrectomy between January 2006 and December 2010. We divided the populations into 3 groups according to BMI; underweight, normal, and overweight. Patients were divided into 3 groups according to BMI (underweight, normal-weight, overweight). PNI was classified into low and high (cutoff value; 49.7). The association of preoperative BMI/PNI and their changes (6 months postoperatively) with clinicopathologic characteristics were evaluated.
RESULTS: Preoperative underweight and low PNI were related to poor prognosis (log-rank p < 0.001 for both). There was a positive correlation between preoperative BMI and PNI (mean preoperative PNI: 51.13 [underweight], 53.37 [normal-weight], and 55.16 [overweight]; p < 0.001). Preoperative BMI and PNI were independent prognostic factors for disease-free survival along with age and TNM stage (p < 0.001 for both). BMI changes from normal-weight to underweight and from overweight to normal/underweight were related to poor prognosis (log-rank p = 0.021 and p = 0.013, respectively). PNI changes were related to prognosis in both the preoperative low and high PNI groups (p < 0.001 and p = 0.019, respectively).
CONCLUSION: Preoperative BMI and PNI and their postoperative changes are related to prognosis in patients with stage II/III gastric cancer. Careful nutritional intervention after gastrectomy can improve prognosis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
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| Enthalten in: |
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 46(2020), 4 Pt A vom: 01. Apr., Seite 620-625 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Park, Su Hyung [VerfasserIn] |
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| Links: |
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| Themen: |
Body mass index |
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| Anmerkungen: |
Date Completed 26.10.2020 Date Revised 26.10.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ejso.2019.10.024 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM302734678 |
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| 245 | 1 | 0 | |a Prognostic significance of body mass index and prognostic nutritional index in stage II/III gastric cancer |
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| 500 | |a Date Revised 26.10.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved. | ||
| 520 | |a INTRODUCTION: Preoperative body weight and nutritional status are related to prognosis in patients with gastric cancer; however, the prognostic impact of postoperative in these variables is unclear. We aimed to investigate the association of preoperative/postoperative body mass index (BMI) and prognostic nutritional index (PNI) with prognosis in patients with gastric cancer | ||
| 520 | |a MATERIALS AND METHODS: We retrospectively 1868 patients with stage II/III gastric cancer treated with gastrectomy between January 2006 and December 2010. We divided the populations into 3 groups according to BMI; underweight, normal, and overweight. Patients were divided into 3 groups according to BMI (underweight, normal-weight, overweight). PNI was classified into low and high (cutoff value; 49.7). The association of preoperative BMI/PNI and their changes (6 months postoperatively) with clinicopathologic characteristics were evaluated | ||
| 520 | |a RESULTS: Preoperative underweight and low PNI were related to poor prognosis (log-rank p < 0.001 for both). There was a positive correlation between preoperative BMI and PNI (mean preoperative PNI: 51.13 [underweight], 53.37 [normal-weight], and 55.16 [overweight]; p < 0.001). Preoperative BMI and PNI were independent prognostic factors for disease-free survival along with age and TNM stage (p < 0.001 for both). BMI changes from normal-weight to underweight and from overweight to normal/underweight were related to poor prognosis (log-rank p = 0.021 and p = 0.013, respectively). PNI changes were related to prognosis in both the preoperative low and high PNI groups (p < 0.001 and p = 0.019, respectively) | ||
| 520 | |a CONCLUSION: Preoperative BMI and PNI and their postoperative changes are related to prognosis in patients with stage II/III gastric cancer. Careful nutritional intervention after gastrectomy can improve prognosis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Body mass index | |
| 650 | 4 | |a Gastric cancer | |
| 650 | 4 | |a Nutrition | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Prognostic nutritional index | |
| 700 | 1 | |a Lee, Sejin |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Jeong Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Seohee |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Minah |e verfasserin |4 aut | |
| 700 | 1 | |a Kwon, In Gyu |e verfasserin |4 aut | |
| 700 | 1 | |a Son, Taeil |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Hyoung-Il |e verfasserin |4 aut | |
| 700 | 1 | |a Cheong, Jae-Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Hyung, Woo Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Seung Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Noh, Sung Hoon |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Yoon Young |e verfasserin |4 aut | |
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